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Target
Carbonic anhydrase 2
Ligand
BDBM11936
Substrate
BDBM11402
Meas. Tech.
In Vitro Binding for Human Carbonic Anhydrase II
pH
7.4±n/a
Temperature
310.15±n/a K
Kd
0.1±.01 nM
Citation
 Boriack-Sjodin, PA; Zeitlin, S; Chen, HH; Crenshaw, L; Gross, S; Dantanarayana, A; Delgado, P; May, JA; Dean, T; Christianson, DW Structural analysis of inhibitor binding to human carbonic anhydrase II. Protein Sci 7:2483-9 (1998) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM11936
Synonyms:
(4R)-2-(3-methoxyphenyl)-4-(methylamino)-1,1-dioxo-2H,3H,4H-1,7,2-thieno[3,2-e][1,2]thiazine-6-sulfonamide | (R)-3,4-DIHYDRO-2-(3-METHOXYPHENYL)-4-METHYLAMINO-2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE-1,1-DIOXIDE | AL7089
Type:
Small organic molecule
Emp. Form.:
C14H17N3O5S3
Mol. Mass.:
403.497
SMILES:
CN[C@H]1CN(c2cccc(OC)c2)S(=O)(=O)c2sc(cc12)S(N)(=O)=O |r|
Structure:
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Substrate
Name:
BDBM11402
Synonyms:
5-(dimethylamino)naphthalene-1-sulfonamide | dansylamide
Type:
Small organic molecule
Emp. Form.:
C12H14N2O2S
Mol. Mass.:
250.317
SMILES:
CN(C)c1cccc2c(cccc12)S(N)(=O)=O
Structure:
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