Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM330226
Substrate
n/a
Meas. Tech.
Human Factor D Assay
IC50
<1000±n/a nM
Citation
Wiles, JA; Hashimoto, A; Gadhachanda, VR; Pais, G; Wang, Q; Chen, D; Wang, X; Agarwal, A; Deshpande, M; Phadke, AS Phosphonate compounds for treatment of complement mediated disorders US Patent US9663543 Publication Date 5/30/2017
More Info.:
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
Inhibitor
Name:
BDBM330226
Synonyms:
US10301336, Comp No. 2 | US9663543, Compound 2 | ethyl hydrogen 3-acetyl-1- (2-((2S,4R)-2-(3-chloro-2- fluorobenzylcarbamoyl)-4- fluoropyrrolidin-1-yl)-2- oxoethyl)-1H-indol-6- ylphosphonate
Type:
Small organic molecule
Emp. Form.:
C26H27ClF2N3O6P
Mol. Mass.:
581.933
SMILES:
CCOP(O)(=O)c1ccc2c(cn(CC(=O)N3C[C@H](F)C[C@H]3C(=O)NCc3cccc(Cl)c3F)c2c1)C(C)=O |r|