Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM340252
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
>10000±n/a nM
Citation
 Wiles, JA; Phadke, AS; Wang, X; Chen, D; Hashimoto, A; Gadhachanda, VR; Pais, G; Wang, Q; Agarwal, A; Deshpande, M Compounds for treatment of complement mediated disorders US Patent  US9758537 Publication Date 9/12/2017 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM340252
Synonyms:
(2S,4R)-1-(2-(3-acetyl- 1H-indol-1- yl)propanoyl)-N-(3- chloro-2-fluorobenzyl)- 4-fluoropyrrolidine-2- carboxamide | US9758537, Compound 55
Type:
Small organic molecule
Emp. Form.:
C25H24ClF2N3O3
Mol. Mass.:
487.926
SMILES:
CC(C(=O)N1C[C@H](F)C[C@H]1C(=O)NCc1cccc(Cl)c1F)n1cc(C(C)=O)c2ccccc12 |r,w:1.0|
Structure:
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