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TargetFactor D
LigandBDBM340258
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
IC50<1000±n/a nM
Citation Wiles, JAPhadke, ASWang, XChen, DHashimoto, AGadhachanda, VRPais, GWang, QAgarwal, ADeshpande, M Compounds for treatment of complement mediated disorders US Patent US9758537 Publication Date 9/12/2017
More Info.:Get all data from this article,  Assay Method
 
Factor D
Name:Complement factor D
Synonyms:Adipsin | C3 convertase activator | CFD | Complement Factor D | DF | PFD | Properdin factor D
Type:Protein
Mol. Mass.:27039.19
Organism:Homo sapiens (Human)
Description:P00746
Residue:253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQW
VLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQL
SEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCN
RRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTR
VASYAAWIDSVLA
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  Blast E-value cutoff:
BDBM340258
NameBDBM340258
Synonyms:US9758537, Compound 61 | diethyl 3-(((2S,4R)-1- (2-(3-acetyl-1H-indol-1- yl)acetyl)-4- fluoropyrrolidine-2- carboxamido)methyl)-5- chloro-4- fluorophenylphosphonate
TypeSmall organic molecule
Emp. Form.C28H31ClF2N3O6P
Mol. Mass.609.986
SMILESCCOP(=O)(OCC)c1cc(Cl)c(F)c(CNC(=O)[C@@H]2C[C@@H](F)CN2C(=O)Cn2cc(C(C)=O)c3ccccc23)c1 |r|
Structure
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