Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 4 [42-168]
Ligand
BDBM345521
Substrate
n/a
Meas. Tech.
In Vitro Enzyme Inhibition Assay-BRD4 Inhibition
IC50
2750±n/a nM
Citation
 Bennett, MJ; Betancort, JM; Boloor, A; Kanouni, T; Stafford, JA; Veal, JM; Wallace, MB Therapeutic compounds US Patent  US10202360 Publication Date 2/12/2019 
Target
Name:
Bromodomain-containing protein 4 [42-168]
Synonyms:
BRD4 | BRD4 BD1 (aa 42-168) | BRD4_HUMAN | Bromodomain-containing protein 4 Bromo Domain 1 | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
15054.68
Organism:
Homo sapiens (Human)
Description:
O60885[42-168]
Residue:
127
Sequence:
STNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE
  
Inhibitor
Name:
BDBM345521
Synonyms:
N-(2-(2,4-difluorophenoxy)-6-(1,5- dimethyl-6-oxo-1,6-dihydropyridin- 3-yl)pyrimidin-4- yl)cyclopentanesulfonamide | US10202360, Example 66
Type:
Small organic molecule
Emp. Form.:
C22H22F2N4O4S
Mol. Mass.:
476.496
SMILES:
Cc1cc(cn(C)c1=O)-c1cc(NS(=O)(=O)C2CCCC2)nc(Oc2ccc(F)cc2F)n1
Structure:
Search PDB for entries with ligand similarity: