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Target
RAC-beta serine/threonine-protein kinase
Ligand
BDBM15217
Substrate
AKTide-2T
Meas. Tech.
PKB In Vitro Enzyme Assay
IC50
3400±n/a nM
Citation
 Collins, I; Caldwell, J; Fonseca, T; Donald, A; Bavetsias, V; Hunter, LJ; Garrett, MD; Rowlands, MG; Aherne, GW; Davies, TG; Berdini, V; Woodhead, SJ; Davis, D; Seavers, LC; Wyatt, PG; Workman, P; McDonald, E Structure-based design of isoquinoline-5-sulfonamide inhibitors of protein kinase B. Bioorg Med Chem 14:1255-73 (2006) [PubMed]  Article 
Target
Name:
RAC-beta serine/threonine-protein kinase
Synonyms:
AKT2 | AKT2_HUMAN | PKB beta | Protein kinase Akt-2 | Protein kinase B (Akt 2) | Protein kinase B beta (AKT2) | Protein kinase B, beta | RAC-PK-beta | RAC-alpha serine/threonine-protein kinase (AKT2) | RAC-beta serine/threonine-protein kinase | RAC-beta serine/threonine-protein kinase (AKT2) | Serine/threonine-protein kinase AKT | Serine/threonine-protein kinase AKT2 | Serine/threonine-protein kinase Rac alpha/beta
Type:
Enzyme
Mol. Mass.:
55766.64
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
481
Sequence:
MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAECQLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPMDYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSASIRE
  
Inhibitor
Name:
BDBM15217
Synonyms:
Isoquinoline-5-sulfonic acid (2S,4S)-(4-(benzyloxy)pyrrolidin-2-yl-methyl)amide | N-{[(2S,4S)-4-(benzyloxy)pyrrolidin-2-yl]methyl}isoquinoline-5-sulfonamide | isoquinoline-5-sulfonamide 49
Type:
Small organic molecule
Emp. Form.:
C21H23N3O3S
Mol. Mass.:
397.491
SMILES:
O=S(=O)(NC[C@@H]1C[C@@H](CN1)OCc1ccccc1)c1cccc2cnccc12 |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
AKTide-2T
Synonyms:
AKT/PKB/Rac Protein Kinase Substrate
Type:
Peptide
Mol. Mass.:
1719.90
Organism:
n/a
Description:
n/a
Residue:
14
Sequence:
ARKRERTYSFGHHA