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Found 1249 with Last Name = 'mcdonald' and Initial = 'e'
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Abbott Laboratories

LigandPNGBDBM194((5R,6R)-1,5-dibenzyl-6-hydroxy-2,4-bis[(4-hydroxy-...)
Affinity DataKi:  0.00500nM ΔG°:  -65.6kJ/molepH: 4.7 T: 2°CAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay using the internally quenched fluorogenic substrate DABCYL-GABA-Ser-Gln-Tyr-P...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM520(1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[...)
Affinity DataKi:  0.0150nMAssay Description:Inhibition constant of ritonavir towards HIV protease was determinedMore data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Abbott Laboratories

LigandPNGBDBM195((5R,6R)-1,5-dibenzyl-2-(cyclopropylmethyl)-6-hydro...)
Affinity DataKi:  0.0620nM ΔG°:  -59.2kJ/molepH: 4.7 T: 2°CAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay using the internally quenched fluorogenic substrate DABCYL-GABA-Ser-Gln-Tyr-P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Abbott Laboratories

LigandPNGBDBM192((5R,6R)-1,5-dibenzyl-6-hydroxy-2,4-bis[(4-hydroxyp...)
Affinity DataKi:  0.0700nM ΔG°:  -58.9kJ/molepH: 4.7 T: 2°CAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay using the internally quenched fluorogenic substrate DABCYL-GABA-Ser-Gln-Tyr-P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Abbott Laboratories

LigandPNGBDBM189((5R,6R)-1,5-dibenzyl-6-hydroxy-2,4-bis({[4-(hydrox...)
Affinity DataKi:  0.220nM ΔG°:  -56.0kJ/molepH: 4.7 T: 2°CAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay using the internally quenched fluorogenic substrate DABCYL-GABA-Ser-Gln-Tyr-P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Abbott Laboratories

LigandPNGBDBM193((5R,6R)-1,5-dibenzyl-6-hydroxy-2,4-bis[(3-methoxyp...)
Affinity DataKi:  0.220nM ΔG°:  -56.0kJ/molepH: 4.7 T: 2°CAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay using the internally quenched fluorogenic substrate DABCYL-GABA-Ser-Gln-Tyr-P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Abbott Laboratories

LigandPNGBDBM190((5R,6R)-2,4-Bis[4-(hydroxymethyl)benzyl]-1-(3-fura...)
Affinity DataKi:  0.490nM ΔG°:  -54.0kJ/molepH: 4.7 T: 2°CAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay using the internally quenched fluorogenic substrate DABCYL-GABA-Ser-Gln-Tyr-P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50016752(CHEMBL339943 | N*1*-[1-(1-Carbamoyl-4-guanidino-bu...)
Affinity DataKi:  1.5nMAssay Description:Inhibition constant for vasopressin-stimulated adenylate cyclase (Vasopressin V2 receptor) of medullary membranes of human kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Abbott Laboratories

LigandPNGBDBM191((5R,6R)-1,2,4,5-tetrabenzyl-6-hydroxy-1,2,4-triaze...)
Affinity DataKi:  2nM ΔG°:  -50.5kJ/molepH: 4.7 T: 2°CAssay Description:HIV-1 protease activity was measured by a continuous fluorometric assay using the internally quenched fluorogenic substrate DABCYL-GABA-Ser-Gln-Tyr-P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50016752(CHEMBL339943 | N*1*-[1-(1-Carbamoyl-4-guanidino-bu...)
Affinity DataKi:  2.90nMAssay Description:Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidney (Vasopressin V2 receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50016760(19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzyl)-...)
Affinity DataKi:  3.30nMAssay Description:Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of human kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50016756(CHEMBL265591 | c(Pmp-D-Tyr(Et)-Phe-Val-Asn-Cys)-Pr...)
Affinity DataKi:  3.70nMAssay Description:Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of human kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50016753(1-[20-Benzyl-14-carbamoylmethyl-23-(4-ethoxy-benzy...)
Affinity DataKi:  4.20nMAssay Description:Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of human kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50016753(1-[20-Benzyl-14-carbamoylmethyl-23-(4-ethoxy-benzy...)
Affinity DataKi:  4.20nMAssay Description:Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50016757(1-[20-Benzyl-14-carbamoylmethyl-23-(4-ethoxy-benzy...)
Affinity DataKi:  4.40nMAssay Description:Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50016757(1-[20-Benzyl-14-carbamoylmethyl-23-(4-ethoxy-benzy...)
Affinity DataKi:  4.40nMAssay Description:Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of human kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50020655(CHEMBL408474 | [6-Amino-2-({1-[19-amino-13-benzyl-...)
Affinity DataKi:  4.60nMAssay Description:Compound was tested for inhibition of hog kidney reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50020655(CHEMBL408474 | [6-Amino-2-({1-[19-amino-13-benzyl-...)
Affinity DataKi:  4.60nMAssay Description:Tested for inhibition of [3H]-LVP binding to vasopressin receptor in medullary membranes of pig kidney.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50016747(1-[20-Benzyl-14-carbamoylmethyl-23-(4-ethoxy-benzy...)
Affinity DataKi:  4.70nMAssay Description:Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50016747(1-[20-Benzyl-14-carbamoylmethyl-23-(4-ethoxy-benzy...)
Affinity DataKi:  4.80nMAssay Description:Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of human kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50016760(19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzyl)-...)
Affinity DataKi:  5.80nMAssay Description:Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50016760(19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzyl)-...)
Affinity DataKi:  5.80nMAssay Description:Tested for inhibition of vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidney.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50016756(CHEMBL265591 | c(Pmp-D-Tyr(Et)-Phe-Val-Asn-Cys)-Pr...)
Affinity DataKi:  6nMAssay Description:Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50020653(1-[19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzy...)
Affinity DataKi:  6.40nMAssay Description:Tested for inhibition of vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidney.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50016755(20-Benzyl-14-carbamoylmethyl-23-(4-ethoxy-benzyl)-...)
Affinity DataKi:  6.60nMAssay Description:Inhibition constant for vasopressin-stimulated adenylate cyclase (Vasopressin V2 receptor) of medullary membranes of human kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50016755(20-Benzyl-14-carbamoylmethyl-23-(4-ethoxy-benzyl)-...)
Affinity DataKi:  6.80nMAssay Description:Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidney (Vasopressin V2 receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50016763(1-[20-Benzyl-14-carbamoylmethyl-23-(4-ethoxy-benzy...)
Affinity DataKi:  7.60nMAssay Description:Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of human kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50016763(1-[20-Benzyl-14-carbamoylmethyl-23-(4-ethoxy-benzy...)
Affinity DataKi:  7.60nMAssay Description:Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50016754(1-[20-Benzyl-14-carbamoylmethyl-23-(4-ethoxy-benzy...)
Affinity DataKi:  8.30nMAssay Description:Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50020656(1-[19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzy...)
Affinity DataKi:  9.40nMAssay Description:Tested for inhibition of vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidney.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50016761(1-[20-Benzyl-14-carbamoylmethyl-23-(4-ethoxy-benzy...)
Affinity DataKi:  9.40nMAssay Description:Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50020656(1-[19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzy...)
Affinity DataKi:  9.40nMAssay Description:Tested for inhibition of vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidney.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50016750(1-[20-Benzyl-14-carbamoylmethyl-23-(4-ethoxy-benzy...)
Affinity DataKi:  11nMAssay Description:Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidney (Vasopressin V2 receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50016762(20-Benzyl-14-carbamoylmethyl-23-(4-ethoxy-benzyl)-...)
Affinity DataKi:  11nMAssay Description:Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidney (Vasopressin V2 receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50254456(CHEMBL447392 | N-(2-chlorobenzyl)-2-(N-(4-isobutox...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]desArg from human B1 in human WI 38 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50020653(1-[19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzy...)
Affinity DataKi:  12nMAssay Description:Tested for inhibition of [3H]-LVP binding to vasopressin receptor in medullary membranes of pig kidney.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50020654(1-[19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzy...)
Affinity DataKi:  12nMAssay Description:Tested for inhibition of [3H]-LVP binding to vasopressin receptor in medullary membranes of pig kidney.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50020654(1-[19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzy...)
Affinity DataKi:  12nMAssay Description:Tested for inhibition of vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidney.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50020651(19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzyl)-...)
Affinity DataKi:  19nMAssay Description:Tested for inhibition of vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidney.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50020651(19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzyl)-...)
Affinity DataKi:  19nMAssay Description:Tested for inhibition of [3H]-LVP binding to vasopressin receptor in medullary membranes of pig kidney.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50254457(CHEMBL443207 | N-(2-chlorobenzyl)-2-(N-(3-chloro-4...)
Affinity DataKi:  21nMAssay Description:Displacement of [3H]desArg from human B1 in human WI 38 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50016760(19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzyl)-...)
Affinity DataKi:  26nMAssay Description:Tested for inhibition of vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidney.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50016749(20-Benzyl-14-carbamoylmethyl-23-(4-ethoxy-benzyl)-...)
Affinity DataKi:  27nMAssay Description:Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidney (Vasopressin V2 receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50016746(1-[20-Benzyl-14-carbamoylmethyl-23-(4-ethoxy-benzy...)
Affinity DataKi:  28nMAssay Description:Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50016759(1-[20-Benzyl-14-carbamoylmethyl-23-(4-ethoxy-benzy...)
Affinity DataKi:  28nMAssay Description:Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidney (Vasopressin V2 receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50020652(1-[19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzy...)
Affinity DataKi:  30nMAssay Description:Tested for inhibition of [3H]-LVP binding to vasopressin receptor in medullary membranes of pig kidney.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50020652(1-[19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzy...)
Affinity DataKi:  30nMAssay Description:Tested for inhibition of [3H]-LVP binding to vasopressin receptor in medullary membranes of pig kidney.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50254458(CHEMBL452238 | N-(2-chlorobenzyl)-2-(N-(4-isobutox...)
Affinity DataKi:  34nMAssay Description:Displacement of [3H]desArg from human B1 in human WI 38 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50254456(CHEMBL447392 | N-(2-chlorobenzyl)-2-(N-(4-isobutox...)
Affinity DataKi:  37nMAssay Description:Antagonist activity at human cloned B1 receptor expressed in african green monkey COS7 cells by calcium mobilization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Sus scrofa)
Smith Kline & French Laboratories

Curated by ChEMBL
LigandPNGBDBM50016748(1-[20-Benzyl-14-carbamoylmethyl-23-(4-ethoxy-benzy...)
Affinity DataKi:  42nMAssay Description:Inhibition constant for vasopressin-stimulated adenylate cyclase of medullary membranes of pig kidney (Vasopressin V2 receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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