Reaction Details Report a problem with these data
Target
RAC-beta serine/threonine-protein kinase
Ligand
BDBM16222
Substrate
AKTide-2T
Meas. Tech.
PKB In Vitro Enzyme Assay
pH
7.2±n/a
Temperature
295.15±n/a K
IC50
230±n/a nM
Citation
 Davies, TG; Verdonk, ML; Graham, B; Saalau-Bethell, S; Hamlett, CC; McHardy, T; Collins, I; Garrett, MD; Workman, P; Woodhead, SJ; Jhoti, H; Barford, D A structural comparison of inhibitor binding to PKB, PKA and PKA-PKB chimera. J Mol Biol 367:882-94 (2007) [PubMed]  Article 
Target
Name:
RAC-beta serine/threonine-protein kinase
Synonyms:
AKT2 | AKT2_HUMAN | PKB beta | Protein kinase Akt-2 | Protein kinase B (Akt 2) | Protein kinase B beta (AKT2) | Protein kinase B, beta | RAC-PK-beta | RAC-alpha serine/threonine-protein kinase (AKT2) | RAC-beta serine/threonine-protein kinase | RAC-beta serine/threonine-protein kinase (AKT2) | Serine/threonine-protein kinase AKT | Serine/threonine-protein kinase AKT2 | Serine/threonine-protein kinase Rac alpha/beta
Type:
Enzyme
Mol. Mass.:
55766.64
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
481
Sequence:
MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAECQLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPMDYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSASIRE
  
Inhibitor
Name:
BDBM16222
Synonyms:
CCT077373 | N-[2-({2-[(4-chlorobenzyl)oxy]ethyl}amino)ethyl]isoquinoline-5-sulfonamide | N-[2-({2-[(4-chlorophenyl)methoxy]ethyl}amino)ethyl]isoquinoline-5-sulfonamide | compound 1 | isoquinoline-5-sulfonamide 9
Type:
Small organic molecule
Emp. Form.:
C20H22ClN3O3S
Mol. Mass.:
419.925
SMILES:
Clc1ccc(COCCNCCNS(=O)(=O)c2cccc3cnccc23)cc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
AKTide-2T
Synonyms:
AKT/PKB/Rac Protein Kinase Substrate
Type:
Peptide
Mol. Mass.:
1719.90
Organism:
n/a
Description:
n/a
Residue:
14
Sequence:
ARKRERTYSFGHHA