Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM351996
Substrate
n/a
Meas. Tech.
Factor D Assay
IC50
<1000±n/a nM
Citation
Gadhachanda, VR; Wang, Q; Pais, G; Hashimoto, A; Chen, D; Wang, X; Agarwal, A; Deshpande, M; Wiles, JA; Phadke, AS Aryl, heteroaryl, and heterocyclic compounds for treatment of complement mediated disorders US Patent US9796741 Publication Date 10/24/2017
More Info.:
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
Inhibitor
Name:
BDBM351996
Synonyms:
(1R,3S,5R)-2-(2-(3- acetyl-5-(pyrimidin-5- yl)-1H-indol-1- yl)acetyl)-N-(2'-chloro- 2-fluorobiphenyl-3-yl)- 2-azabicyclo[3.1.0] hexane-3-carboxamide | US10287301, Compound 15 | US10822352, Comp No. 15 | US9796741, cmp No. 15
Type:
Small organic molecule
Emp. Form.:
C34H27ClFN5O3
Mol. Mass.:
608.061
SMILES:
CC(=O)c1cn(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)Nc2cccc(c2F)-c2ccccc2Cl)c2ccc(cc12)-c1cncnc1 |r|