Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM354243
Substrate
n/a
Meas. Tech.
Factor D Assay
IC50
5050±n/a nM
Citation
 Gadhachanda, VR; Wang, Q; Pais, G; Hashimoto, A; Chen, D; Wang, X; Agarwal, A; Deshpande, M; Wiles, JA; Phadke, AS Aryl, heteroaryl, and heterocyclic compounds for treatment of complement mediated disorders US Patent  US9796741 Publication Date 10/24/2017 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM354243
Synonyms:
(2S,4R)-1-(2-(3-acetyl- 5-(pyridazin-4-yl)-1H- indol-1-yl)acetyl)-4- fluoro-N-(1-(1-methyl- 1H-pyrazol-4- yl)piperidin-3- yl)pyrrolidine-2- carboxamide | US10287301, Compound 140 | US10822352, Comp No. 140 | US9796741, cmp No. 140
Type:
Small organic molecule
Emp. Form.:
C30H33FN8O3
Mol. Mass.:
572.6332
SMILES:
CC(=O)c1cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)NC2CCCN(C2)c2cnn(C)c2)c2ccc(cc12)-c1ccnnc1 |r|
Structure:
Search PDB for entries with ligand similarity: