Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM357844
Substrate
n/a
Meas. Tech.
FLIPR Ca2+ Flux Assay
IC50
49.0±n/a nM
Citation
 Kuduk, SD; Liverton, N; Luo, Y Hydroxmethyl piperidine orexin receptor antagonists US Patent  US10214535 Publication Date 2/26/2019 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM357844
Synonyms:
US10214535, Example 4 | methyl 2-cyano-6-{[(3R,6S)-6- (hydroxymethyl)-1-{[2-(2H- 1,2,3-triazol-2-yl)phenyl] carbonyl}piperidin-3-yl]oxy} benzoate
Type:
Small organic molecule
Emp. Form.:
C24H23N5O5
Mol. Mass.:
461.4699
SMILES:
COC(=O)c1c(O[C@@H]2CC[C@@H](CO)N(C2)C(=O)c2ccccc2-n2nccn2)cccc1C#N |r|
Structure:
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