Target

Ligand

Substrate

Meas. Tech.

Akt1 Kinase Assay

pH

7.5±n/a

Temperature

295.15±n/a K

Citation

 Lippa, B; Pan, G; Corbett, M; Li, C; Kauffman, GS; Pandit, J; Robinson, S; Wei, L; Kozina, E; Marr, ES; Borzillo, G; Knauth, E; Barbacci-Tobin, EG; Vincent, P; Troutman, M; Baker, D; Rajamohan, F; Kakar, S; Clark, T; Morris, J Synthesis and structure based optimization of novel Akt inhibitors. Bioorg Med Chem Lett 18:3359-63 (2008) [PubMed]  Article Copy BDB DOI

More Info.:

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Name:

RAC-alpha serine/threonine-protein kinase

Synonyms:

AKT phosphorylation (p-AKT) | AKT1 | AKT1/PPP1CA | AKT1_HUMAN | C-AKT | PKB | PKB alpha | Protein kinase Akt-1 | Protein kinase B | Protein kinase B (AKT1) | Protein kinase B (Akt 1) | Protein kinase B (Akt) | Protein kinase B alpha | Protein kinase B alpha (AKT1) | Proto-oncogene Akt (Akt1) | Proto-oncogene c-Akt (AKT) | Proto-oncogene c-Akt (AKT1) | RAC | RAC-PK-alpha | RAC-alpha serine/threonine-protein kinase (AKT) | RAC-alpha serine/threonine-protein kinase (AKT1) | RAC-alpha serine/threonine-protein kinase (pAKT)

Type:

Enzyme

Mol. Mass.:

55681.25

Organism:

Homo sapiens (Human)

Description:

P31749

Residue:

480

Sequence:

MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA

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Blast E-value cutoff:

Name:

BDBM24840

Synonyms:

5-chloro-N-[2-(4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine | pyrrolopyrimidine, 5c

Type:

Small organic molecule

Emp. Form.:

C14H10ClN7

Mol. Mass.:

311.729

SMILES:

Clc1c[nH]c2ncnc(Nc3ccccc3-c3nnc[nH]3)c12

Structure:

Search PDB for entries with ligand similarity:

Similarity to this molecule at least:

Name:

Fluorescent-labeled Crosstide

Synonyms:

5(6)-Carboxytetramethylrhodamine-labeled peptide | TAMRA-labeled peptide

Type:

Fluorescent dye labeled peptide

Mol. Mass.:

1165.24

Organism:

n/a

Description:

n/a

Residue:

11

Sequence:

GRPRTSSFAEG