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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM384558
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
82.0±n/a nM
Citation
 Altman, MD; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; Maclean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Smith, GF Inhibitors of IRAK4 activity US Patent  US9932350 Publication Date 4/3/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM384558
Synonyms:
N-[trans-4-(morpholin-4- yl)cyclohexyl]-6-(propan- 2-yloxy)quinazolin-4- amine | US9932350, 2-10
Type:
Small organic molecule
Emp. Form.:
C21H30N4O2
Mol. Mass.:
370.4885
SMILES:
CC(C)Oc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1 |r,wU:13.12,wD:16.19,(.39,7.32,;-.38,5.99,;.39,4.65,;-1.92,5.99,;-2.69,4.65,;-4.23,4.65,;-5,3.32,;-4.23,1.99,;-5,.65,;-4.23,-.68,;-2.69,-.68,;-1.92,.65,;-.38,.65,;.39,-.68,;1.93,-.68,;2.7,-2.02,;1.93,-3.35,;.39,-3.35,;-.38,-2.02,;2.7,-4.68,;1.93,-6.02,;2.72,-7.32,;4.24,-7.32,;5,-6,;4.24,-4.68,;-2.69,1.99,;-1.92,3.32,)|
Structure:
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