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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM384576
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
11.0±n/a nM
Citation
 Altman, MD; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; Maclean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Smith, GF Inhibitors of IRAK4 activity US Patent  US9932350 Publication Date 4/3/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM384576
Synonyms:
4-({trans-4-[4- (methylsulfonyl)piperidin- 1- yl]cyclohexyl}amino) quinazoline-6-carbonitrile | US9932350, 3-10
Type:
Small organic molecule
Emp. Form.:
C21H27N5O2S
Mol. Mass.:
413.536
SMILES:
CS(=O)(=O)C1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N |r,wU:13.17,wD:10.10,(3,5.44,;4.34,4.67,;5.11,6,;5.67,3.9,;3.57,3.33,;4.34,2,;3.57,.67,;2.03,.67,;1.26,2,;2.03,3.33,;1.26,-.67,;-.28,-.67,;-1.05,-2,;-.28,-3.33,;1.26,-3.33,;2.03,-2,;-1.05,-4.67,;-2.59,-4.67,;-3.36,-6,;-4.9,-6,;-5.67,-4.67,;-4.9,-3.33,;-5.67,-2,;-4.9,-.67,;-3.36,-.67,;-2.59,-2,;-3.36,-3.33,;-2.59,.67,;-1.82,2,)|
Structure:
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