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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM384595
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
11.0±n/a nM
Citation
 Altman, MD; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; Maclean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Smith, GF Inhibitors of IRAK4 activity US Patent  US9932350 Publication Date 4/3/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM384595
Synonyms:
4-{[trans-4-(3- methoxyazetidin-1- yl)cyclohexyl]amino} quinazoline-6-carbonitrile | US9932350, 3-29
Type:
Small organic molecule
Emp. Form.:
C19H23N5O
Mol. Mass.:
337.4188
SMILES:
COC1CN(C1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N |r,wU:9.13,wD:6.6,(5.55,-7.61,;4.01,-7.61,;3.24,-6.28,;1.75,-5.88,;2.15,-4.39,;3.64,-4.79,;1.38,-3.06,;2.15,-1.72,;1.38,-.39,;-.16,-.39,;-.93,-1.72,;-.16,-3.06,;-.93,.94,;-2.47,.94,;-3.24,-.39,;-4.78,-.39,;-5.55,.94,;-4.78,2.28,;-5.55,3.61,;-4.78,4.94,;-3.24,4.94,;-2.47,3.61,;-3.24,2.28,;-2.47,6.28,;-1.7,7.61,)|
Structure:
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