Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM330236
Substrate
n/a
Meas. Tech.
Human Factor D Assay
IC50
<1000±n/a nM
Citation
Wiles, JA; Hashimoto, A; Gadhachanda, VR; Pais, G; Wang, Q; Chen, D; Wang, X; Agarwal, A; Deshpande, M; Phadke, A Phosphonate compounds for treatment of complement mediated disorders US Patent US10301336 Publication Date 5/28/2019
More Info.:
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
Inhibitor
Name:
BDBM330236
Synonyms:
1-(2-((2S,4R)-2-(3-chloro- 2-fluorobenzylcarbamoyl)- 4-fluoropyrrolidin-1-yl)-2- oxoethyl)-6- (diethoxyphosphoryl)-1H- indazole-3-carboxylic acid | US10301336, Comp No. 12 | US9663543, Compound 12
Type:
Small organic molecule
Emp. Form.:
C26H28ClF2N4O7P
Mol. Mass.:
612.947
SMILES:
CCOP(=O)(OCC)c1ccc2c(nn(CC(=O)N3C[C@H](F)C[C@H]3C(=O)NCc3cccc(Cl)c3F)c2c1)C(O)=O |r|