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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM393945
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
71.0±n/a nM
Citation
 Altman, MD; Andresen, BM; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; MacLean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Torres, L Inhibitors of IRAK4 activity US Patent  US9969749 Publication Date 5/15/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM393945
Synonyms:
US9969749, Example 1-38 | trans-N'-[6-(3- methoxypyridin-4- yl)quinazolin-4-yl]-N,N- dimethylcyclohexane- 1,4-diamine
Type:
Small organic molecule
Emp. Form.:
C22H27N5O
Mol. Mass.:
377.4827
SMILES:
COc1cnccc1-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N(C)C)c2c1 |r,wU:20.24,wD:17.17,(2.31,3.33,;.77,3.33,;,4.67,;.77,6,;,7.34,;-1.54,7.34,;-2.31,6,;-1.54,4.67,;-2.31,3.33,;-3.85,3.33,;-4.62,2,;-3.85,.67,;-4.62,-.67,;-3.85,-2,;-2.31,-2,;-1.54,-.67,;,-.67,;.77,-2,;,-3.33,;.77,-4.67,;2.31,-4.67,;3.08,-3.33,;2.31,-2,;3.08,-6,;4.62,-6,;2.31,-7.34,;-2.31,.67,;-1.54,2,)|
Structure:
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