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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM393975
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
5.00±n/a nM
Citation
 Altman, MD; Andresen, BM; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; MacLean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Torres, L Inhibitors of IRAK4 activity US Patent  US9969749 Publication Date 5/15/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM393975
Synonyms:
3-fluoro-5-{4-[(trans- 4-morpholin-4- ylcyclohexyl)amino] quinazolin-6-yl}phenol | US9969749, Example 1-66
Type:
Small organic molecule
Emp. Form.:
C24H27FN4O2
Mol. Mass.:
422.4952
SMILES:
Oc1cc(F)cc(c1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1 |r,wU:17.17,wD:20.24,(1.92,6,;.39,6,;-.38,7.34,;-1.92,7.34,;-2.69,8.67,;-2.69,6,;-1.92,4.67,;-.38,4.67,;-2.69,3.33,;-4.23,3.33,;-5,2,;-4.23,.67,;-5,-.67,;-4.23,-2,;-2.69,-2,;-1.92,-.67,;-.38,-.67,;.39,-2,;1.93,-2,;2.7,-3.33,;1.93,-4.67,;.39,-4.67,;-.38,-3.33,;2.7,-6,;1.92,-7.34,;2.7,-8.67,;4.23,-8.67,;5,-7.34,;4.23,-6,;-2.69,.67,;-1.92,2,)|
Structure:
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