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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM394028
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
48.0±n/a nM
Citation
 Altman, MD; Andresen, BM; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; MacLean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Torres, L Inhibitors of IRAK4 activity US Patent  US9969749 Publication Date 5/15/2018 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM394028
Synonyms:
6-(2,3-dihydro-1H- pyrrolo[3,2-b]pyridin-6- yl)-N-[trans-4- (morpholin-4- yl)cyclohexyl]quinazolin- 4-amine | US9969749, Example 2-16
Type:
Small organic molecule
Emp. Form.:
C25H30N6O
Mol. Mass.:
430.5453
SMILES:
C1Cc2ncc(cc2N1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1 |r,wU:21.26,wD:18.19,(-1.15,9.19,;.09,8.28,;-.38,6.82,;.38,5.48,;-.38,4.15,;-1.93,4.15,;-2.69,5.48,;-1.93,6.82,;-2.4,8.28,;-2.69,2.82,;-4.23,2.82,;-5,1.48,;-4.23,.15,;-5,-1.18,;-4.23,-2.52,;-2.69,-2.52,;-1.93,-1.18,;-.38,-1.18,;.38,-2.52,;-.39,-3.85,;.38,-5.19,;1.92,-5.19,;2.69,-3.85,;1.92,-2.52,;2.69,-6.52,;1.92,-7.85,;2.69,-9.19,;4.23,-9.19,;5,-7.85,;4.23,-6.52,;-2.69,.15,;-1.93,1.48,)|
Structure:
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