Reaction Details Report a problem with these data
Target
Transcription activator BRG1 [1448-1575]
Ligand
BDBM394449
Substrate
n/a
Meas. Tech.
BRG1 TR-FRET Binding Assay
IC50
10.6±n/a nM
Citation
 Albrecht, BK; Cote, A; Crawford, T; Duplessis, M; Good, AC; LeBlanc, Y; Magnuson, SR; Nasveschuk, CG; Romero, FA; Tang, Y; Taylor, AM Therapeutic compounds and uses thereof US Patent  US10308614 Publication Date 6/4/2019 
Target
Name:
Transcription activator BRG1 [1448-1575]
Synonyms:
ATP-dependent helicase SMARCA4 | BAF190A | BRG1 | His-BRG1 (A1448-S1575) | SMARCA4 | SMCA4_HUMAN | SNF2B | SNF2L4 | Transcription activator BRG1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
14937.42
Organism:
Homo sapiens (Human)
Description:
P51532(A1448-S1575)
Residue:
128
Sequence:
AEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSVRQKIEKEDDSEGEES
  
Inhibitor
Name:
BDBM394449
Synonyms:
2-(6-amino-5-(8- | US10308614, Example 50
Type:
Small organic molecule
Emp. Form.:
C20H21N7O
Mol. Mass.:
375.427
SMILES:
Nc1nnc(cc1N1CC2CCC(C1)N2c1cnccn1)-c1ccccc1O |TLB:15:14:10.11:7.8.13|
Structure:
Search PDB for entries with ligand similarity: