Reaction Details Report a problem with these data
Target
Malignant T-cell-amplified sequence 1
Ligand
BDBM402882
Substrate
n/a
Meas. Tech.
MTT assay
EC50
100.0±n/a nM
Citation
 Bannister, TD; Roush, WR; Choi, JY; Nair, R; Tsai, AS; Mishra, JK; Cleveland, JL Heterocyclic inhibitors of monocarboxylate transporter US Patent  US10329303 Publication Date 6/25/2019 
Target
Name:
Malignant T-cell-amplified sequence 1
Synonyms:
MCT-1 | MCT1 | MCTS1 | MCTS1_HUMAN | Multiple copies T-cell malignancies
Type:
Enzyme Catalytic Domain
Mol. Mass.:
20563.62
Organism:
Homo sapiens (human)
Description:
n/a
Residue:
181
Sequence:
MFKKFDEKENVSNCIQLKTSVIKGIKNQLIEQFPGIEPWLNQIMPKKDPVKIVRCHEHIEILTVNGELLFFRQREGPFYPTLRLLHKYPFILPHQQVDKGAIKFVLSGANIMCPGLTSPGAKLYPAAVDTIVAIMAEGKQHALCVGVMKMSAEDIEKVNKGIGIENIHYLNDGLWHMKTYK
  
Inhibitor
Name:
BDBM402882
Synonyms:
US10329303, Example 2
Type:
Small organic molecule
Emp. Form.:
C25H29FN4O3S
Mol. Mass.:
484.586
SMILES:
CC(C)Cn1c2sc(Cc3c(C)n[nH]c3C)c(-c3cc(C)cc(CO)c3F)c2c(=O)n(C)c1=O |(-4.16,-5.89,;-4.16,-4.35,;-5.5,-3.58,;-2.83,-3.58,;-2.83,-2.04,;-1.49,-1.27,;-.03,-1.75,;.88,-.5,;2.42,-.5,;3.19,-1.84,;2.71,-3.3,;1.38,-4.07,;3.96,-4.21,;5.2,-3.3,;4.73,-1.84,;5.5,-.5,;-.03,.74,;.37,2.23,;-.72,3.32,;-.32,4.81,;-1.41,5.89,;1.17,5.2,;2.25,4.12,;3.74,4.51,;4.83,3.42,;1.86,2.63,;2.95,1.54,;-1.49,.27,;-2.83,1.04,;-2.83,2.58,;-4.16,.27,;-5.5,1.04,;-4.16,-1.27,;-5.5,-2.04,)|
Structure:
Search PDB for entries with ligand similarity: