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Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM404296
Substrate
n/a
Meas. Tech.
FLIPR Ca2+ Flux Assay
IC50
1900±n/a nM
Citation
 Liverton, N; Kuduk, SD; Beshore, D; Luo, Y; Meng, N; Yu, T Piperidine isoxazole and isothiazole orexin receptor antagonists US Patent  US10017504 Publication Date 7/10/2018 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:
Protein
Mol. Mass.:
47554.50
Organism:
Homo sapiens (Human)
Description:
O43613
Residue:
425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
  
Inhibitor
Name:
BDBM404296
Synonyms:
1-[2-({(2R,5R)-5-[3-(1-Hydroxy- 1-methylethyl)isoxazol-5-yl]-2- methylpiperidin-1- yl}carbonyl)phenyl]cyclopropane carbonitrile | US10017504, 29
Type:
Small organic molecule
Emp. Form.:
C23H27N3O3
Mol. Mass.:
393.4788
SMILES:
C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1C1(CC1)C#N)c1cc(no1)C(C)(C)O
Structure:
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