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Found 876 with Last Name = 'meng' and Initial = 'n'
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426423(1-(2-((2R,5R)-5-((3- (difluoromethyl)imidazo[1,2-a...)
Affinity DataIC50:  5nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM401852(2-{5-mMethyl-2-[(3R,6R)-6- methyl-1-{[2-(2,2,2- tr...)
Affinity DataIC50:  6.90nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetOrexin receptor type 2(Homo sapiens (Human))
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426469((2-(2H-1,2,3-triazol-2-yl)phenyl)((2R,5R)-5-((3-br...)
Affinity DataIC50:  7.30nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM401808((2-(2H-1,2,3-triazol-2-yl)phenyl)((2R,5R)-5-(4-(2-...)
Affinity DataIC50:  7.5nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM401853(2-(2-{(3R,6R)-1-[(2- Ethoxyphenyl)carbonyl]-6- met...)
Affinity DataIC50:  7.90nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426387((2-(2H-1,2,3-triazol-2-yl)phenyl)((2R,5R)-2-methyl...)
Affinity DataIC50:  8nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM401805(2-{2-[(3R,6R)-1-({2-[(1S)-2,2-difluorocyclopropyl]...)
Affinity DataIC50:  8.5nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM404296(1-[2-({(2R,5R)-5-[3-(1-Hydroxy- 1-methylethyl)isox...)
Affinity DataIC50:  8.80nMAssay Description:n a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM401854(2-(2-{(3R,6R)-1-[(2- Cyclopropylphenyl)carbonyl]-6...)
Affinity DataIC50:  8.80nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
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TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM401848(2-{2-[(3R,6R)-1-{[2-(2,2- Difluoroethoxy)pyridin-3...)
Affinity DataIC50:  8.80nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
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TargetOrexin receptor type 2(Homo sapiens (Human))
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426414((2-(2H-1,2,3-triazol-2-yl)phenyl)((2R,5R)-5-((3-br...)
Affinity DataIC50:  8.90nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426407((2-(2H-1,2,3-triazol-2-yl)phenyl)((2R,5R)-5-((3-ch...)
Affinity DataIC50:  9.10nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM401855(2-{5-Methyl-2-[(3R,6R)-6- methyl-1-{[2-(1H-pyrazol...)
Affinity DataIC50:  9.30nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM401889((2R)-1,1,1-Trifluoro-2-{1-[(3R,6R)-6-methyl-1-{[2-...)
Affinity DataIC50:  9.40nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
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TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM401869(2-{1-[(3R,6R)-1-({2-[(1S)-2,2- Difluorocyclopropyl...)
Affinity DataIC50:  9.40nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM101857(US9695163, 9)
Affinity DataIC50:  9.40nMT: 2°CAssay Description:Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426409(1-(2-((2R,5R)-5-((3- chloroimidazo[1,2-alpha] pyr...)
Affinity DataIC50:  9.5nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM401850(2-{2-[(3R,6R)-1-{[2- (Difluoromethoxy)phenyl] carb...)
Affinity DataIC50:  9.60nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
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TargetOrexin receptor type 2(Homo sapiens (Human))
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426425((2-(2H-tetrazol-2-yl)phenyl)((2R,5R)-5- ((3-(difl...)
Affinity DataIC50:  9.60nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426451((2-(2H-1,2,3-triazol-2-yl)thiophen-3-yl)((2R,5R)-2...)
Affinity DataIC50:  9.80nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360351(US9828368, Example 13 | US9828368, Example 14 | US...)
Affinity DataIC50:  10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM401851(2-{5-Methyl-2-[(3R,6R)-6- methyl-1-{[2- (trifluoro...)
Affinity DataIC50:  10.1nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetOrexin receptor type 2(Homo sapiens (Human))
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426386((2-(2H-1,2,3-triazol-2-yl)phenyl)((2R,5R)-5-(imida...)
Affinity DataIC50:  10.3nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426421((2-(2H-1,2,3-triazol-2-yl)thiophen-3- yl)((2R,5R)-...)
Affinity DataIC50:  10.5nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM401890(US10010539, 106)
Affinity DataIC50:  10.6nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM360364(US9828368, Example 25)
Affinity DataIC50:  10.7nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetOrexin receptor type 2(Homo sapiens (Human))
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM404309(((1R)-2,2,2-Trifluoro-1-{5-[(3R,6R)-6-methyl-1-{[2...)
Affinity DataIC50:  11nMAssay Description:n a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM360376(US9828368, Example 35)
Affinity DataIC50:  11.7nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM101899(US9695163, 25)
Affinity DataIC50:  12nMT: 2°CAssay Description:Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM101883(US9695163, 20)
Affinity DataIC50:  12nMT: 2°CAssay Description:Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM360366(US9828368, Example 27)
Affinity DataIC50:  12nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426407((2-(2H-1,2,3-triazol-2-yl)phenyl)((2R,5R)-5-((3-ch...)
Affinity DataIC50:  12.1nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM401802(((2R,5R)-5-(4-(2-Hydroxypropan-2-yl)-2H-1,2,3-tria...)
Affinity DataIC50:  12.1nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM401846(2-{5-Methyl-2-[(3R,6R)-6-methyl-1-{[2-(2H-1,2,3-tr...)
Affinity DataIC50:  12.5nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426413((2-(2H-1,2,3-triazol-2-yl)phenyl)((2R,5R)-5-((3-fl...)
Affinity DataIC50:  12.6nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM360351(US9828368, Example 13 | US9828368, Example 14 | US...)
Affinity DataIC50:  12.8nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetOrexin receptor type 2(Homo sapiens (Human))
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426440(1-(2-((2R,5R)-2-methyl-5-((3- (trifluoromethyl)imi...)
Affinity DataIC50:  12.8nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM101911(US9695163, 30)
Affinity DataIC50:  13nMT: 2°CAssay Description:Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426414((2-(2H-1,2,3-triazol-2-yl)phenyl)((2R,5R)-5-((3-br...)
Affinity DataIC50:  13.1nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426390(1-(2-((2R,5R)-2-methyl-5-((2- methylimidazo[1,2-al...)
Affinity DataIC50:  13.2nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM401888(1,1,1-Trifluoro-2-{1-[(3R,6R)-6-methyl-1-{[2-(2H-1...)
Affinity DataIC50:  13.4nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetOrexin receptor type 2(Homo sapiens (Human))
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM50108616(CHEMBL3597957 | US9828368, Example 24)
Affinity DataIC50:  13.5nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM401891(2-{3-Methyl-1-[(3R,6R)-6-methyl-1-{[2-(2H-1,2,3-tr...)
Affinity DataIC50:  13.8nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM401784(1-(2-((2R,5R)-5-(4-(2-Hydroxypropan-2-yl)-2H-1,2,3...)
Affinity DataIC50:  13.8nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetOrexin receptor type 2(Homo sapiens (Human))
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM360356(US9828368, Example 18 | US9828368, Example 19)
Affinity DataIC50:  13.9nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetOrexin receptor type 2(Homo sapiens (Human))
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426411((2-(2H-1,2,3-triazol-2-yl)phenyl)((2R,5R)-5-((3-ch...)
Affinity DataIC50:  13.9nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM404327(2-{3-[(3R,6R)-6-Methyl-1-{[2-(2H-1,2,3-triazol-2-y...)
Affinity DataIC50:  13.9nMAssay Description:n a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM50108614(CHEMBL3597959 | US9695163, 19)
Affinity DataIC50:  14nMT: 2°CAssay Description:Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM50108615(CHEMBL3597958 | US9695163, 35)
Affinity DataIC50:  14nMT: 2°CAssay Description:Briefly, for intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the orexin-1 receptor (e.g., rat or human) or the orexi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426487((2-(2H-1,2,3-triazol-2-yl)phenyl)((2R,5R)-5-(imida...)
Affinity DataIC50:  14nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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