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Target
Orexin receptor type 2
Ligand
BDBM426423
Substrate
n/a
Meas. Tech.
FLIPR Assay
IC50
5.00±n/a nM
Citation
 Kuduk, SD; Liverton, N; Beshore, DC; Meng, N; Luo, Y Fused heteroaryl derivatives as orexin receptor antagonists US Patent  US10526336 Publication Date 1/7/2020 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM426423
Synonyms:
1-(2-((2R,5R)-5-((3- (difluoromethyl)imidazo[1,2-alpha]pyrazin-8- yl)oxy)-2-methylpiperidine-1- carbonyl)phenyl)cyclopropanecarbonitrile | US10526336, Example 42
Type:
Small organic molecule
Emp. Form.:
C25H24F2N4O2
Mol. Mass.:
450.4805
SMILES:
C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1C1(CC1)C#C)Oc1nccn2c(cnc12)C(F)F |r|
Structure:
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