Reaction Details Report a problem with these data
Target
Adenosine receptor A2b
Ligand
BDBM50242116
Substrate
n/a
Meas. Tech.
ChEMBL_1671313 (CHEMBL4021342)
Ki
1.6±n/a nM
Citation
 Basu, S; Barawkar, DA; Ramdas, V; Patel, M; Waman, Y; Panmand, A; Kumar, S; Thorat, S; Naykodi, M; Goswami, A; Reddy, BS; Prasad, V; Chaturvedi, S; Quraishi, A; Menon, S; Paliwal, S; Kulkarni, A; Karande, V; Ghosh, I; Mustafa, S; De, S; Jain, V; Banerjee, ER; Rouduri, SR; Palle, VP; Chugh, A; Mookhtiar, KA Design and synthesis of novel xanthine derivatives as potent and selective A Eur J Med Chem 134:218-229 (2017) [PubMed]  Article 
Target
Name:
Adenosine receptor A2b
Synonyms:
AA2BR_HUMAN | ADENOSINE A2B | ADORA2B | Adenosine receptor A2B (A2B) | Adenosine receptors A2b | Adenosine receptors; A2a & A2b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36341.22
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
332
Sequence:
MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQPALGVGL
  
Inhibitor
Name:
BDBM50242116
Synonyms:
CHEMBL4079273
Type:
Small organic molecule
Emp. Form.:
C20H17FN6O2
Mol. Mass.:
392.3864
SMILES:
CCCn1c(=O)[nH]c2nc([nH]c2c1=O)-c1cnn(CC#Cc2ccc(F)cc2)c1
Structure:
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