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Target
Mu-type opioid receptor
Ligand
BDBM50007421
Substrate
n/a
Meas. Tech.
ChEBML_148698
IC50
9.5±n/a nM
Citation
 Iorio, MA; Frigeni, V; Bowman, ER; Harris, LS; May, EL; Aceto, MD Common stereospecificity of opioid and dopamine systems for N-butyrophenone prodine-like compounds. J Med Chem 34:194-7 (1991) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44503.11
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor.
Residue:
398
Sequence:
MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50007421
Synonyms:
CHEMBL59245 | Propionic acid 1-[4-(4-fluoro-phenyl)-4-oxo-butyl]-3-methyl-4-phenyl-piperidin-4-yl ester
Type:
Small organic molecule
Emp. Form.:
C25H30FNO3
Mol. Mass.:
411.509
SMILES:
CCC(=O)O[C@]1(CCN(CCCC(=O)c2ccc(F)cc2)CC1C)c1ccccc1
Structure:
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