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Found 56 with Last Name = 'iorio' and Initial = 'ma'
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Istituto Superiore Di Sanità

Curated by ChEMBL
LigandPNGBDBM50009591(1-(2-Methyl-1-phenyl-cyclohexyl)-piperidine | CHEM...)
Affinity DataKi:  11nMAssay Description:Binding affinity of the compound was determined by displacement of [3H]-TCP from PCP N-methyl-D-aspartate glutamate receptor of tissue homogenate pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Istituto Superiore Di Sanità

Curated by ChEMBL
LigandPNGBDBM50009591(1-(2-Methyl-1-phenyl-cyclohexyl)-piperidine | CHEM...)
Affinity DataKi:  25nMAssay Description:Binding affinity by displacement of [3H]TCP from PCP N-methyl-D-aspartate glutamate receptor of tissue homogenate preparation of rat brain without ce...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Istituto Superiore Di Sanità

Curated by ChEMBL
LigandPNGBDBM83449(1-(1-phenylcyclohexyl)piperidine;hydrochloride | M...)
Affinity DataKi:  53nMAssay Description:Binding affinity of the compound was determined by displacement of [3H]-TCP from PCP N-methyl-D-aspartate glutamate receptor of tissue homogenate pre...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Istituto Superiore Di Sanità

Curated by ChEMBL
LigandPNGBDBM50009592(CHEMBL424610 | cis-1-(4-Methyl-1-phenyl-cyclohexyl...)
Affinity DataKi:  617nMAssay Description:Binding affinity of the compound was determined by displacement of [3H]-TCP from PCP N-methyl-D-aspartate glutamate receptor of tissue homogenate pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Istituto Superiore Di Sanità

Curated by ChEMBL
LigandPNGBDBM50009592(CHEMBL424610 | cis-1-(4-Methyl-1-phenyl-cyclohexyl...)
Affinity DataKi:  617nMAssay Description:Binding affinity of the compound was determined by displacement of [3H]-TCP from PCP N-methyl-D-aspartate glutamate receptor of tissue homogenate pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Istituto Superiore Di Sanità

Curated by ChEMBL
LigandPNGBDBM50009591(1-(2-Methyl-1-phenyl-cyclohexyl)-piperidine | CHEM...)
Affinity DataKi:  2.18E+3nMAssay Description:Binding affinity of the compound was determined by displacement of [3H]-TCP from PCP N-methyl-D-aspartate glutamate receptor of tissue homogenate pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Istituto Superiore Di Sanità

Curated by ChEMBL
LigandPNGBDBM50009591(1-(2-Methyl-1-phenyl-cyclohexyl)-piperidine | CHEM...)
Affinity DataKi:  2.94E+3nMAssay Description:Binding affinity by displacement of [3H]TCP from PCP N-methyl-D-aspartate glutamate receptor of tissue homogenate preparation of rat brain without ce...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Istituto Superiore Di Sanità

Curated by ChEMBL
LigandPNGBDBM50009590(CHEMBL86824 | cis-C-(2-Methyl-1-piperidin-1-yl-cyc...)
Affinity DataKi:  4.70E+3nMAssay Description:Binding affinity of the compound was determined by displacement of [3H]-TCP from PCP N-methyl-D-aspartate glutamate receptor of tissue homogenate pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Istituto Superiore Di Sanità

Curated by ChEMBL
LigandPNGBDBM50009590(CHEMBL86824 | cis-C-(2-Methyl-1-piperidin-1-yl-cyc...)
Affinity DataKi:  4.70E+3nMAssay Description:Binding affinity of the compound was determined by displacement of [3H]-TCP from PCP N-methyl-D-aspartate glutamate receptor of tissue homogenate pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Istituto Superiore Di Sanità

Curated by ChEMBL
LigandPNGBDBM50009591(1-(2-Methyl-1-phenyl-cyclohexyl)-piperidine | CHEM...)
Affinity DataKi:  7.40E+3nMAssay Description:Binding affinity by displacement of [3H]TCP from PCP N-methyl-D-aspartate glutamate receptor of tissue homogenate preparation of rat brain without ce...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Istituto Superiore Di Sanità

Curated by ChEMBL
LigandPNGBDBM50009591(1-(2-Methyl-1-phenyl-cyclohexyl)-piperidine | CHEM...)
Affinity DataKi:  7.40E+3nMAssay Description:Binding affinity by displacement of [3H]TCP from PCP N-methyl-D-aspartate glutamate receptor of tissue homogenate preparation of rat brain without ce...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Istituto Superiore Di Sanità

Curated by ChEMBL
LigandPNGBDBM50009593(C-Phenyl-C-(1-piperidin-1-yl-cyclohexyl)-methylene...)
Affinity DataKi:  3.10E+4nMAssay Description:Binding affinity of the compound was determined by displacement of [3H]-TCP from PCP N-methyl-D-aspartate glutamate receptor of tissue homogenate pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Istituto Superiore Di Sanità

Curated by ChEMBL
LigandPNGBDBM50000092((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Affinity DataIC50:  1.60nMAssay Description:Opioid receptor activity in terms of inhibition of [3H]-dihydromorphine binding in rat brain membraneMore data for this Ligand-Target Pair
LigandPNGBDBM50000092((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Affinity DataIC50:  1.60nMAssay Description:Ability to inhibit the specific binding of [3H]- dihydromorphine to opiate receptors in rat brain membrane preparation by 50%More data for this Ligand-Target Pair
LigandPNGBDBM50019947(CHEMBL299471 | Propionic acid 1-[4-(4-fluoro-pheny...)
Affinity DataIC50:  3nMAssay Description:Ability to inhibit the specific binding of [3H]- dihydromorphine to opiate receptors in rat brain membrane preparation by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50019948(CHEMBL292006 | Propionic acid 1-[4-(4-fluoro-pheny...)
Affinity DataIC50:  3.30nMAssay Description:Ability to inhibit the specific binding of [3H]- dihydromorphine to opiate receptors in rat brain membrane preparation by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Istituto Superiore Di Sanità

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50:  4.20nMAssay Description:Neuroleptic activity in terms of [3H]-spiroperidol binding in rat striatal membraneto Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Istituto Superiore Di Sanità

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50:  4.20nMAssay Description:Ability to inhibit the specific binding of [3H]- spiroperidol to Dopamine receptor D2 in rat striatal membrane preparation by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Istituto Superiore Di Sanità

Curated by ChEMBL
LigandPNGBDBM50007421(CHEMBL59245 | Propionic acid 1-[4-(4-fluoro-phenyl...)
Affinity DataIC50:  6.10nMAssay Description:Opioid activity in terms of inhibition of [3H]-dihydromorphine binding to opioid receptor mu in rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50019946(CHEMBL56547 | Propionic acid 1-[4-(4-fluoro-phenyl...)
Affinity DataIC50:  8.70nMAssay Description:Ability to inhibit the specific binding of [3H]- dihydromorphine to opiate receptors in rat brain membrane preparation by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Istituto Superiore Di Sanità

Curated by ChEMBL
LigandPNGBDBM50007421(CHEMBL59245 | Propionic acid 1-[4-(4-fluoro-phenyl...)
Affinity DataIC50:  9.5nMAssay Description:Opioid activity in terms of inhibition of [3H]-dihydromorphine binding to Opioid receptor mu 1 in rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50:  24nMAssay Description:Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Istituto Superiore Di Sanità

Curated by ChEMBL
LigandPNGBDBM50019947(CHEMBL299471 | Propionic acid 1-[4-(4-fluoro-pheny...)
Affinity DataIC50:  29nMAssay Description:Ability to inhibit the specific binding of [3H]- spiroperidol to Dopamine receptor D2 in rat striatal membrane preparation by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Istituto Superiore Di Sanità

Curated by ChEMBL
LigandPNGBDBM50019948(CHEMBL292006 | Propionic acid 1-[4-(4-fluoro-pheny...)
Affinity DataIC50:  34nMAssay Description:Ability to inhibit the specific binding of [3H]- spiroperidol to Dopamine receptor D2 in rat striatal membrane preparation by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Istituto Superiore Di Sanità

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50:  41nMAssay Description:Ability to inhibit the specific binding of [3H]- spiroperidol to Dopamine receptor D2 in rat striatal membrane preparation by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Istituto Superiore Di Sanità

Curated by ChEMBL
LigandPNGBDBM50007421(CHEMBL59245 | Propionic acid 1-[4-(4-fluoro-phenyl...)
Affinity DataIC50:  43nMAssay Description:Neuroleptic activity in terms of [3H]-spiroperidol binding to dopamine receptor D2 in rat striatal membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Istituto Superiore Di Sanità

Curated by ChEMBL
LigandPNGBDBM50019949(1-(4-Fluoro-phenyl)-4-(4-hydroxy-4-phenyl-piperidi...)
Affinity DataIC50:  47nMAssay Description:Ability to inhibit the specific binding of [3H]- spiroperidol to Dopamine receptor D2 in rat striatal membrane preparation by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Istituto Superiore Di Sanità

Curated by ChEMBL
LigandPNGBDBM50019946(CHEMBL56547 | Propionic acid 1-[4-(4-fluoro-phenyl...)
Affinity DataIC50:  47nMAssay Description:Ability to inhibit the specific binding of [3H]- spiroperidol to Dopamine receptor D2 in rat striatal membrane preparation by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Istituto Superiore Di Sanità

Curated by ChEMBL
LigandPNGBDBM50007421(CHEMBL59245 | Propionic acid 1-[4-(4-fluoro-phenyl...)
Affinity DataIC50:  54nMAssay Description:Neuroleptic activity in terms of [3H]-spiroperidol binding to Dopamine receptor D2 in rat striatal membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Istituto Superiore Di Sanità

Curated by ChEMBL
LigandPNGBDBM50019954(1-(4-Fluoro-phenyl)-4-(4-hydroxy-3-methyl-4-phenyl...)
Affinity DataIC50:  55nMAssay Description:Ability to inhibit the specific binding of [3H]- spiroperidol to Dopamine receptor D2 in rat striatal membrane preparation by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Istituto Superiore Di Sanità

Curated by ChEMBL
LigandPNGBDBM50019950(1-(4-Fluoro-phenyl)-4-(4-phenyl-piperidin-1-yl)-bu...)
Affinity DataIC50:  70nMAssay Description:Ability to inhibit the specific binding of [3H]- spiroperidol to Dopamine receptor D2 in rat striatal membrane preparation by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Istituto Superiore Di Sanità

Curated by ChEMBL
LigandPNGBDBM50019945(1-(4-Fluoro-phenyl)-4-(4-hydroxy-3-methyl-4-phenyl...)
Affinity DataIC50:  80nMAssay Description:Ability to inhibit the specific binding of [3H]- spiroperidol to Dopamine receptor D2 in rat striatal membrane preparation by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Istituto Superiore Di Sanità

Curated by ChEMBL
LigandPNGBDBM50007420(CHEMBL418289 | Propionic acid 1-[4-(4-fluoro-pheny...)
Affinity DataIC50:  147nMAssay Description:Neuroleptic activity in terms of [3H]-spiroperidol binding to Dopamine receptor D2 in rat striatal membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM29644((6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...)
Affinity DataIC50:  302nMAssay Description:Ability to inhibit the specific binding of [3H]- dihydromorphine to opiate receptors in rat brain membrane preparation by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Istituto Superiore Di Sanità

Curated by ChEMBL
LigandPNGBDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)
Affinity DataIC50:  302nMAssay Description:Neuroleptic activity in terms of [3H]-spiroperidol binding in rat striatal membrane to Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(RAT)
Istituto Superiore Di Sanit£

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50:  550nMAssay Description:Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50019952(CHEMBL57306 | Propionic acid 1-[4-(4-fluoro-phenyl...)
Affinity DataIC50:  598nMAssay Description:Ability to inhibit the specific binding of [3H]- spiroperidol to Dopamine receptor D2 in rat striatal membrane preparation by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(RAT)
Istituto Superiore Di Sanit£

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(RAT)
Istituto Superiore Di Sanit£

Curated by ChEMBL
LigandPNGBDBM50019954(1-(4-Fluoro-phenyl)-4-(4-hydroxy-3-methyl-4-phenyl...)
Affinity DataIC50:  1.65E+3nMAssay Description:Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Istituto Superiore Di Sanità

Curated by ChEMBL
LigandPNGBDBM50007420(CHEMBL418289 | Propionic acid 1-[4-(4-fluoro-pheny...)
Affinity DataIC50:  1.79E+3nMAssay Description:Opioid activity in terms of inhibition of [3H]-dihydromorphine binding to Opioid receptor mu 1 in rat brain membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(RAT)
Istituto Superiore Di Sanit£

Curated by ChEMBL
LigandPNGBDBM50019947(CHEMBL299471 | Propionic acid 1-[4-(4-fluoro-pheny...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(RAT)
Istituto Superiore Di Sanit£

Curated by ChEMBL
LigandPNGBDBM50019948(CHEMBL292006 | Propionic acid 1-[4-(4-fluoro-pheny...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(RAT)
Istituto Superiore Di Sanit£

Curated by ChEMBL
LigandPNGBDBM50019945(1-(4-Fluoro-phenyl)-4-(4-hydroxy-3-methyl-4-phenyl...)
Affinity DataIC50:  2.65E+3nMAssay Description:Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(RAT)
Istituto Superiore Di Sanit£

Curated by ChEMBL
LigandPNGBDBM50019949(1-(4-Fluoro-phenyl)-4-(4-hydroxy-4-phenyl-piperidi...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM55121(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)
Affinity DataIC50:  3.05E+3nMAssay Description:Ability to inhibit the specific binding of [3H]- dihydromorphine to opiate receptors in rat brain membrane preparation by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Istituto Superiore Di Sanità

Curated by ChEMBL
LigandPNGBDBM55121(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)
Affinity DataIC50:  3.05E+3nMAssay Description:Neuroleptic activity in terms of [3H]-spiroperidol binding in rat striatal membrane to Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(RAT)
Istituto Superiore Di Sanit£

Curated by ChEMBL
LigandPNGBDBM50019946(CHEMBL56547 | Propionic acid 1-[4-(4-fluoro-phenyl...)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50019949(1-(4-Fluoro-phenyl)-4-(4-hydroxy-4-phenyl-piperidi...)
Affinity DataIC50:  3.22E+3nMAssay Description:Ability to inhibit the specific binding of [3H]- dihydromorphine to opiate receptors in rat brain membrane preparation by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Istituto Superiore Di Sanità

Curated by ChEMBL
LigandPNGBDBM50019953(1-(4-Fluoro-phenyl)-4-(4-hydroxy-piperidin-1-yl)-b...)
Affinity DataIC50: >5.00E+3nMAssay Description:Ability to inhibit the specific binding of [3H]- spiroperidol to Dopamine receptor D2 in rat striatal membrane preparation by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50019953(1-(4-Fluoro-phenyl)-4-(4-hydroxy-piperidin-1-yl)-b...)
Affinity DataIC50:  5.50E+3nMAssay Description:Ability to inhibit the specific binding of [3H]- dihydromorphine to opiate receptors in rat brain membrane preparation by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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