Reaction Details Report a problem with these data
Target
Type-2 angiotensin II receptor
Ligand
BDBM50011970
Substrate
n/a
Meas. Tech.
ChEBML_36494
IC50
6000±n/a nM
Citation
 Weinstock, J; Keenan, RM; Samanen, J; Hempel, J; Finkelstein, JA; Franz, RG; Gaitanopoulos, DE; Girard, GR; Gleason, JG; Hill, DT 1-(carboxybenzyl)imidazole-5-acrylic acids: potent and selective angiotensin II receptor antagonists. J Med Chem 34:1514-7 (1991) [PubMed]  Article 
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2_RAT | AT2 | Agtr2 | Angiotensin II AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41346.62
Organism:
RAT
Description:
Angiotensin II AT2 0 0::P35351
Residue:
363
Sequence:
MKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHLEAIPVLYYMIFVIGFAVNIVVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGIINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSCRKSSSLREMDTFVS
  
Inhibitor
Name:
BDBM50011970
Synonyms:
2-[2-Butyl-5-(2-carboxy-3-thiophen-2-yl-propenyl)-imidazol-1-ylmethyl]-benzoic acid | CHEMBL39349
Type:
Small organic molecule
Emp. Form.:
C23H24N2O4S
Mol. Mass.:
424.513
SMILES:
CCCCc1ncc(\C=C(/Cc2cccs2)C(O)=O)n1Cc1ccccc1C(O)=O
Structure:
Search PDB for entries with ligand similarity: