Reaction Details Report a problem with these data
Target
G-protein coupled bile acid receptor 1
Ligand
BDBM50271983
Substrate
n/a
Meas. Tech.
ChEMBL_1711749 (CHEMBL4121798)
EC50
17±n/a nM
Citation
 Agarwal, S; Sasane, S; Kumar, J; Deshmukh, P; Bhayani, H; Giri, P; Giri, S; Soman, S; Kulkarni, N; Jain, M Evaluation of novel TGR5 agonist in combination with Sitagliptin for possible treatment of type 2 diabetes. Bioorg Med Chem Lett 28:1849-1852 (2018) [PubMed]  Article 
Target
Name:
G-protein coupled bile acid receptor 1
Synonyms:
BG37 | GPBAR1 | GPBAR_HUMAN | M-BAR | TGR5 | hBG37 | hGPCR19
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
35260.02
Organism:
Homo sapiens (Human)
Description:
CHO cells transiently transfected with hTGR5.
Residue:
330
Sequence:
MTPNSTGEVPSPIPKGALGLSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLAGLLTGLALPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAVLRPLQPPGSIRLALLLTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAPYLYLEVYGLLLPAVGAAAFLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPYVATLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRYTAPWRAAAQRCLQGLWGRASRDSPGPSIAYHPSSQSSVDLDLN
  
Inhibitor
Name:
BDBM50271983
Synonyms:
CHEMBL4128655
Type:
Small organic molecule
Emp. Form.:
C29H30ClFN2O3S
Mol. Mass.:
541.077
SMILES:
COc1ccc(cc1OC)C(C)(C)c1cnc(SCCOCc2cccc(Cl)c2)n1-c1ccc(F)cc1
Structure:
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