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Target
DNA topoisomerase 4 subunit A
Ligand
BDBM50474896
Substrate
n/a
Meas. Tech.
ChEMBL_306028 (CHEMBL829954)
IC50
733±n/a nM
Citation
 Inagaki, H; Takahashi, H; Takemura, M Synthesis and antibacterial activity of novel 6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-4-oxoquinoline-3-carboxylic acids bearing cyclopropane-fused 2-amino-8-azabicyclo[4.3.0]nonan-8-yl substituents at the C-7 position. Bioorg Med Chem Lett 14:5193-8 (2004) [PubMed]  Article 
Target
Name:
DNA topoisomerase 4 subunit A
Synonyms:
5.6.2.2 | DNA topoisomerase 4 subunit A | PARC_STAAM | Topoisomerase IV subunit A | parC
Type:
PROTEIN
Mol. Mass.:
91039.06
Organism:
Staphylococcus aureus subsp. aureus Mu50
Description:
ChEMBL_20011
Residue:
800
Sequence:
MSEIIQDLSLEDVLGDRFGRYSKYIIQERALPDVRDGLKPVQRRILYAMYSSGNTHDKNFRKSAKTVGDVIGQYHPHGDFSVYEAMVRLSQDWKLRHVLIEMHGNNGSIDNDPPAAMRYTEAKLSLLAEELLRDINKETVSFIPNYDDTTLEPMVLPSRFPNLLVNGSTGISAGYATDIPPHNLAEVIQATLKYIDNPDITVNQLMKYIKGPDFPTGGIIQGIDGIKKAYESGKGRIIVRSKVEEETLRNGRKQLIITEIPYEVNKSSLVKRIDELRADKKVDGIVEVRDETDRTGLRIAIELKKDVNSESIKNYLYKNSDLQISYNFNMVAISDGRPKLMGIRQIIDSYLNHQIEVVANRTKFELDNAEKRMHIVEGLIKALSILDKVIELIRSSKNKRDAKENLIEVFEFTEEQAEAIVMLQLYRLTNTDIVALEGEHKELEALIKQLRHILDNHDALLNVIKEELNEIKKKFKSERLSLIEAEIEEIKIDKEVMVPSEEVILSMTRHGYIKRTSIRSFNASGVEDIGLKDGDSLLKHQEVNTQDTVLVFTNKGRYLFIPVHKLADIRWKELGQHVSQIVPIEEDEVVINVFNEKDFNTDAFYVFATQNGMIKKSTVPLFKTTRFNKPLIATKVKENDDLISVMRFEKDQLITVITNKGMSLTYNTSELSDTGLRAAGVKSINLKAEDFVVMTEGVSENDTILMATQRGSLKRISFKILQVAKRAQRGITLLKELKKNPHRIVAAHVVTGEHSQYTLYSKSNEEHGLINDIHKSEQYTNGSFIVDTDDFGEVIDMYIS
  
Inhibitor
Name:
BDBM50474896
Synonyms:
CHEMBL184167
Type:
Small organic molecule
Emp. Form.:
C21H23F3N4O3
Mol. Mass.:
436.4275
SMILES:
[H][C@@]1(F)CN(C[C@]1([H])C1CC1N)c1c(C)c2n(cc(C(O)=O)c(=O)c2c(N)c1F)[C@@H]1C[C@@H]1F
Structure:
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