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Target
Growth hormone secretagogue receptor type 1
Ligand
BDBM50412954
Substrate
n/a
Meas. Tech.
ChEMBL_458616 (CHEMBL941945)
EC50
0.158489±n/a nM
Citation
 Heightman, TD; Scott, JS; Longley, M; Bordas, V; Dean, DK; Elliott, R; Hutley, G; Witherington, J; Abberley, L; Passingham, B; Berlanga, M; de Los Frailes, M; Wise, A; Powney, B; Muir, A; McKay, F; Butler, S; Winborn, K; Gardner, C; Darton, J; Campbell, C; Sanger, G Potent achiral agonists of the ghrelin (growth hormone secretagogue) receptor. Part I: Lead identification. Bioorg Med Chem Lett 17:6584-7 (2007) [PubMed]  Article 
Target
Name:
Growth hormone secretagogue receptor type 1
Synonyms:
GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a)
Type:
Receptor
Mol. Mass.:
41334.57
Organism:
Homo sapiens (Human)
Description:
Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a.
Residue:
366
Sequence:
MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
  
Inhibitor
Name:
BDBM50412954
Synonyms:
CHEMBL251572 | SB-791016 | SB-791016A
Type:
Small organic molecule
Emp. Form.:
C24H28N4O3S2
Mol. Mass.:
484.634
SMILES:
COc1cc2CCN(c2cc1N1C[C@H](C)N[C@H](C)C1)S(=O)(=O)c1ccc(s1)-c1ccccn1 |r|
Structure:
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