Reaction Details Report a problem with these data
Target
Mu-type opioid/Nociceptin receptor
Ligand
BDBM50492403
Substrate
n/a
Meas. Tech.
ChEMBL_971895 (CHEMBL2405345)
EC50
1660±n/a nM
Citation
 Zamfirova, R; Pavlov, N; Todorov, P; Mateeva, P; Martinez, J; Calmès, M; Naydenova, E Synthesis and changes in affinity for NOP and opioid receptors of novel hexapeptides containing ?(2)-tryptophan analogues. Bioorg Med Chem Lett 23:4052-5 (2013) [PubMed]  Article 
Target
Name:
Mu-type opioid/Nociceptin receptor
Synonyms:
Nociceptin/mu opioid receptor
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 971895
Components:
This complex has 2 components.
Component 1
Name:
Mu-type opioid receptor
Synonyms:
MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44503.11
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor.
Residue:
398
Sequence:
MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
  
Component 2
Name:
Nociceptin receptor
Synonyms:
Nociceptin/Orphanin FQ, NOP receptor | Nociceptin/mu opioid receptor | OPRX_RAT | Oor | Oprl | Oprl1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40531.08
Organism:
RAT
Description:
Nociceptin/Orphanin FQ, NOP receptor 0 RAT::P35370
Residue:
367
Sequence:
MESLFPAPYWEVLYGSHFQGNLSLLNETVPHHLLLNASHSAFLPLGLKVTIVGLYLAVCIGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPAPQDYWGPVFAICIFLFSFIIPVLIISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPGSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASSLHREMQVSDRVRSIAKDVGLGCKTSETVPRPA
  
Inhibitor
Name:
BDBM50492403
Synonyms:
CHEMBL2403213
Type:
Small organic molecule
Emp. Form.:
C45H68N12O8S2
Mol. Mass.:
969.227
SMILES:
COc1ccc2[nH]cc([C@H](CNC(=O)[C@H](CCSC)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(N)=O)c2c1 |r|
Structure:
Search PDB for entries with ligand similarity: