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Target
Purine nucleoside phosphorylase
Ligand
BDBM50049973
Substrate
n/a
Meas. Tech.
ChEMBL_162192 (CHEMBL873424)
Ki
7300±n/a nM
Citation
 Beauchamp, LM; Tuttle, JV; Rodriguez, ME; Sznaidman, ML Guanine, pyrazolo[3,4-d]pyrimidine, and triazolo[4,5-d]pyrimidine (8-azaguanine) phosphonate acyclic derivatives as inhibitors of purine nucleoside phosphorylase. J Med Chem 39:949-56 (1996) [PubMed]  Article 
Target
Name:
Purine nucleoside phosphorylase
Synonyms:
Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase)
Type:
Enzyme
Mol. Mass.:
32119.53
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
289
Sequence:
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
  
Inhibitor
Name:
BDBM50049973
Synonyms:
CHEMBL175305 | [4-(5-Amino-7-oxo-6,7-dihydro-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-butyl]-phosphonic acid
Type:
Small organic molecule
Emp. Form.:
C8H13N6O4P
Mol. Mass.:
288.2004
SMILES:
Nc1nc2n(CCCCP(O)(O)=O)nnc2c(=O)[nH]1
Structure:
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