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Target
Nuclear receptor subfamily 5 group A member 2
Ligand
BDBM50505380
Substrate
n/a
Meas. Tech.
ChEMBL_1822622 (CHEMBL4322386)
EC50
500±n/a nM
Citation
 Mays, SG; Flynn, AR; Cornelison, JL; Okafor, CD; Wang, H; Wang, G; Huang, X; Donaldson, HN; Millings, EJ; Polavarapu, R; Moore, DD; Calvert, JW; Jui, NT; Ortlund, EA Development of the First Low Nanomolar Liver Receptor Homolog-1 Agonist through Structure-guided Design. J Med Chem 62:11022-11034 (2019) [PubMed]  Article 
Target
Name:
Nuclear receptor subfamily 5 group A member 2
Synonyms:
Alpha-1-fetoprotein transcription factor | B1-binding factor | B1F | CPF | CYP7A promoter-binding factor | FTF | Hepatocytic transcription factor | LRH-1 | Liver Receptor Homolog 1 | NR5A2 | NR5A2_HUMAN | Nuclear receptor subfamily 5 group A member 2 | hB1F | nuclear receptor subfamily 5 group A member 2 isoform 2
Type:
Nuclear Hormone Receptor
Mol. Mass.:
61341.37
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
541
Sequence:
MSSNSDTGDLQESLKHGLTPIGAGLPDRHGSPIPARGRLVMLPKVETEALGLARSHGEQGQMPENMQVSQFKMVNYSYDEDLEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKRYTCIENQNCQIDKTQRKRCPYCRFQKCLSVGMKLEAVRADRMRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMSQVIQAMPSDLTISSAIQNIHSASKGLPLNHAALPPTDYDRSPFVTSPISMTMPPHGSLQGYQTYGHFPSRAIKSEYPDPYTSSPESIMGYSYMDSYQTSSPASIPHLILELLKCEPDEPQVQAKIMAYLQQEQANRSKHEKLSTFGLMCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVVHGKEGSIFLVTGQQVDYSIIASQAGATLNNLMSHAQELVAKLRSLQFDQREFVCLKFLVLFSLDVKNLENFQLVEGVQEQVNAALLDYTMCNYPQQTEKFGQLLLRLPEIRAISMQAEEYLYYKHLNGDVPYNNLLIEMLHAKRA
  
Inhibitor
Name:
BDBM50505380
Synonyms:
CHEMBL4541939
Type:
Small organic molecule
Emp. Form.:
C29H36N2O
Mol. Mass.:
428.6089
SMILES:
[H][C@@]12CC(CCCCCC)=C(c3ccccc3)[C@@]1(CC[C@@H]2NC(N)=O)C(=C)c1ccccc1 |r,t:9|
Structure:
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