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Target
Genome polyprotein
Ligand
BDBM50087781
Substrate
n/a
Meas. Tech.
ChEMBL_76921 (CHEMBL688665)
EC50
600±n/a nM
Citation
 Reich, SH; Johnson, T; Wallace, MB; Kephart, SE; Fuhrman, SA; Worland, ST; Matthews, DA; Hendrickson, TF; Chan, F; Meador, J; Ferre, RA; Brown, EL; DeLisle, DM; Patick, AK; Binford, SL; Ford, CE Substituted benzamide inhibitors of human rhinovirus 3C protease: structure-based design, synthesis, and biological evaluation. J Med Chem 43:1670-83 (2000) [PubMed]  Article 
Target
Name:
Genome polyprotein
Synonyms:
Human rhinovirus A protease | Human rhinovirus B 3A protease
Type:
PROTEIN
Mol. Mass.:
44361.04
Organism:
Human rhinovirus B
Description:
ChEMBL_158953
Residue:
401
Sequence:
AFRPCNVNTKIGNAKCCPFVCGKAVTFKDRSTCSTYNLSSSLHHILEEDKRRRQVVDVMSAIFQGPISLDAPPPPAIADLLQSVRTPRVIKYCQIIMGHPAECQVERDLNIANSIIAIIANIISIAGIIFVIYKLFCSLQGPYSGEPKPKTKVPERRVVAQGPEEEFGRSILKNNTCVITTGNGKFTGLGIHDRILIIPTHADPGREVQVNGVHTKVLDSYDLYNRDGVKLEITVIQLDRNEKFRDIRKYIPETEDDYPECNLALSANQDEPTIIKVGDVVSYGNILLSGNQTARMLKYNYPTKSGYCGGVLYKIGQILGIHVGGNGRDGFSAMLLRSYFTGQIKVNKHATECGLPDIQTIHTPSKTKLQPSVFYDVFPGSKEPAVLTDNDPRLEVNFKEA
  
Inhibitor
Name:
BDBM50087781
Synonyms:
3-{3-Carbamoyl-5-[4-(2-cyano-phenyl)-piperazin-1-ylmethyl]-phenyl}-acrylic acid ethyl ester | CHEMBL44888
Type:
Small organic molecule
Emp. Form.:
C24H26N4O3
Mol. Mass.:
418.4882
SMILES:
CCOC(=O)\C=C\c1cc(CN2CCN(CC2)c2ccccc2C#N)cc(c1)C(N)=O
Structure:
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