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Target
Peptidyl-prolyl cis-trans isomerase FKBP1A
Ligand
BDBM50132541
Substrate
n/a
Meas. Tech.
ChEBML_66292
IC50
8.20±n/a nM
Citation
 Yang, W; Keenan, TP; Rozamus, LW; Wang, X; Rivera, VM; Rollins, CT; Clackson, T; Holt, DA Regulation of gene expression by synthetic dimerizers with novel specificity. Bioorg Med Chem Lett 13:3181-4 (2003) [PubMed]  Article 
Target
Name:
Peptidyl-prolyl cis-trans isomerase FKBP1A
Synonyms:
12 kDa FK506-binding protein | 12 kDa FKBP | FK506-binding protein 1A | FK506-binding protein 1A (FKBP12) | FKB1A_HUMAN | FKBP-12 | FKBP-1A | FKBP1 | FKBP12 | FKBP1A | Immunophilin FKBP12 | PPIase | PPIase FKBP1A | Peptidyl-prolyl cis-trans isomerase (FKBP) | Rotamase | RyR1/FKBP12 | mTOR/FKBP12A/FKBP12B
Type:
Isomerase
Mol. Mass.:
11953.09
Organism:
Homo sapiens (Human)
Description:
P62942
Residue:
108
Sequence:
MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE
  
Inhibitor
Name:
BDBM50132541
Synonyms:
(S)-1-[(S)-2-(3,4,5-Trimethoxy-phenyl)-butyryl]-piperidine-2-carboxylic acid (R)-1-(3-carboxymethoxy-phenyl)-3-(3,4-dimethoxy-phenyl)-propyl ester | 2-(3-((R)-3-(3,4-dimethoxyphenyl)-1-((S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carbonyloxy)propyl)phenoxy)acetic acid | CHEMBL110674 | {3-[3-(3,4-DIMETHOXY-PHENYL)-1-(1-{1-[2-(3,4,5-TRIMETHOXY-PHENYL)-BUTYRYL]-PIPERIDIN-2YL}-VINYLOXY)-PROPYL]-PHENOXY}-ACETIC ACID
Type:
Small organic molecule
Emp. Form.:
C38H47NO11
Mol. Mass.:
693.7799
SMILES:
CC[C@H](C(=O)N1CCCC[C@H]1C(=O)O[C@H](CCc1ccc(OC)c(OC)c1)c1cccc(OCC(O)=O)c1)c1cc(OC)c(OC)c(OC)c1 |r|
Structure:
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