Reaction Details Report a problem with these data
Target
Integrase
Ligand
BDBM50145364
Substrate
n/a
Meas. Tech.
ChEBML_88783
IC50
>100000±n/a nM
Citation
Bénard, C; Zouhiri, F; Normand-Bayle, M; Danet, M; Desmaële, D; Leh, H; Mouscadet, JF; Mbemba, G; Thomas, CM; Bonnenfant, S; Le Bret, M; d'Angelo, J Linker-modified quinoline derivatives targeting HIV-1 integrase: synthesis and biological activity. Bioorg Med Chem Lett 14:2473-6 (2004) [PubMed] Article
More Info.:
Target
Name:
Integrase
Synonyms:
Human immunodeficiency virus type 1 integrase
Type:
PROTEIN
Mol. Mass.:
32231.48
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_90865
Residue:
288
Sequence:
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
Inhibitor
Name:
BDBM50145364
Synonyms:
2-(3,5-Dihydroxy-benzylcarbamoyl)-8-hydroxy-quinoline-7-carboxylic acid | 2-(3,5-dihydroxybenzylcarbamoyl)-8-hydroxyquinoline-7-carboxylic acid | CHEMBL83419
Type:
Small organic molecule
Emp. Form.:
C18H14N2O6
Mol. Mass.:
354.3136
SMILES:
OC(=O)c1ccc2ccc(nc2c1O)C(=O)NCc1cc(O)cc(O)c1