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Target
Hormone-sensitive lipase
Ligand
BDBM50147259
Substrate
n/a
Meas. Tech.
ChEBML_88045
IC50
24±n/a nM
Citation
 Lowe, DB; Magnuson, S; Qi, N; Campbell, AM; Cook, J; Hong, Z; Wang, M; Rodriguez, M; Achebe, F; Kluender, H; Wong, WC; Bullock, WH; Salhanick, AI; Witman-Jones, T; Bowling, ME; Keiper, C; Clairmont, KB In vitro SAR of (5-(2H)-isoxazolonyl) ureas, potent inhibitors of hormone-sensitive lipase. Bioorg Med Chem Lett 14:3155-9 (2004) [PubMed]  Article 
Target
Name:
Hormone-sensitive lipase
Synonyms:
HSL | Hormone sensitive lipase | Hormone-sensitive lipase (HSL) | LIPE | LIPS_HUMAN
Type:
Protein
Mol. Mass.:
116599.07
Organism:
Homo sapiens (Human)
Description:
Q05469
Residue:
1076
Sequence:
MEPGSKSVSRSDWQPEPHQRPITPLEPGPEKTPIAQPESKTLQGSNTQQKPASNQRPLTQQETPAQHDAESQKEPRAQQKSASQEEFLAPQKPAPQQSPYIQRVLLTQQEAASQQGPGLGKESITQQEPALRQRHVAQPGPGPGEPPPAQQEAESTPAAQAKPGAKREPSAPTESTSQETPEQSDKQTTPVQGAKSKQGSLTELGFLTKLQELSIQRSALEWKALSEWVTDSESESDVGSSSDTDSPATMGGMVAQGVKLGFKGKSGYKVMSGYSGTSPHEKTSARNHRHYQDTASRLIHNMDLRTMTQSLVTLAEDNIAFFSSQGPGETAQRLSGVFAGVREQALGLEPALGRLLGVAHLFDLDPETPANGYRSLVHTARCCLAHLLHKSRYVASNRRSIFFRTSHNLAELEAYLAALTQLRALVYYAQRLLVTNRPGVLFFEGDEGLTADFLREYVTLHKGCFYGRCLGFQFTPAIRPFLQTISIGLVSFGEHYKRNETGLSVAASSLFTSGRFAIDPELRGAEFERITQNLDVHFWKAFWNITEMEVLSSLANMASATVRVSRLLSLPPEAFEMPLTADPTLTVTISPPLAHTGPGPVLVRLISYDLREGQDSEELSSLIKSNGQRSLELWPRPQQAPRSRSLIVHFHGGGFVAQTSRSHEPYLKSWAQELGAPIISIDYSLAPEAPFPRALEECFFAYCWAIKHCALLGSTGERICLAGDSAGGNLCFTVALRAAAYGVRVPDGIMAAYPATMLQPAASPSRLLSLMDPLLPLSVLSKCVSAYAGAKTEDHSNSDQKALGMMGLVRRDTALLLRDFRLGASSWLNSFLELSGRKSQKMSEPIAEPMRRSVSEAALAQPQGPLGTDSLKNLTLRDLSLRGNSETSSDTPEMSLSAETLSPSTPSDVNFLLPPEDAGEEAEAKNELSPMDRGLGVRAAFPEGFHPRRSSQGATQMPLYSSPIVKNPFMSPLLAPDSMLKSLPPVHIVACALDPMLDDSVMLARRLRNLGQPVTLRVVEDLPHGFLTLAALCRETRQAAELCVERIRLVLTPPAGAGPSGETGAAGVDGGCGGRH
  
Inhibitor
Name:
BDBM50147259
Synonyms:
4-Cyclopentyl-3-methyl-2-(4-phenyl-piperidine-1-carbonyl)-2H-isoxazol-5-one | 4-cyclopentyl-3-methyl-2-(4-phenylpiperidine-1-carbonyl)isoxazol-5(2H)-one | CHEMBL320708
Type:
Small organic molecule
Emp. Form.:
C21H26N2O3
Mol. Mass.:
354.4427
SMILES:
Cc1c(C2CCCC2)c(=O)on1C(=O)N1CCC(CC1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: