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Target
TYR_PHOSPHATASE_2 domain-containing protein
Ligand
BDBM50175709
Substrate
n/a
Meas. Tech.
ChEMBL_328177 (CHEMBL863943)
IC50
>100000±n/a nM
Citation
 Weide, T; Arve, L; Prinz, H; Waldmann, H; Kessler, H 3-Substituted indolizine-1-carbonitrile derivatives as phosphatase inhibitors. Bioorg Med Chem Lett 16:59-63 (2005) [PubMed]  Article 
Target
Name:
TYR_PHOSPHATASE_2 domain-containing protein
Synonyms:
(PROTEIN-TYROSINE-PHOSPHATASE) (PTPase) | MPtpB | PHOSPHOTYROSINE PROTEIN PHOSPHATASE PTPB | Phosphotyrosine protein phosphatase | Phosphotyrosine-protein phosphatase PTPB | Protein Tyrosine Phosphatase PTPB
Type:
Hydrolase
Mol. Mass.:
30152.45
Organism:
Mycobacterium tuberculosis
Description:
n/a
Residue:
276
Sequence:
MAVRELPGAWNFRDVADTATALRPGRLFRSSELSRLDDAGRATLRRLGITDVADLRSSREVARRGPGRVPDGIDVHLLPFPDLADDDADDSAPHETAFKRLLTNDGSNGESGESSQSINDAATRYMTDEYRQFPTRNGAQRALHRVVTLLAAGRPVLTHCFAGKDRTGFVVALVLEAVGLDRDVIVADYLRSNDSVPQLRARISEMIQQRFDTELAPEVVTFTKARLSDGVLGVRAEYLAAARQTIDETYGSLGGYLRDAGISQATVNRMRGVLLG
  
Inhibitor
Name:
BDBM50175709
Synonyms:
6-(((S)-1-(2-carboxy-1-phenylethylamino)-4-methyl-1-oxopentan-2-yl)carbamoyl)-1-cyanoindolizine-3-carboxylic acid | CHEMBL427374
Type:
Small organic molecule
Emp. Form.:
C26H26N4O6
Mol. Mass.:
490.5078
SMILES:
CC(C)C[C@H](NC(=O)c1ccc2c(cc(C(O)=O)n2c1)C#N)C(=O)NC(CC(O)=O)c1ccccc1
Structure:
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