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Found 673 with Last Name = 'waldmann' and Initial = 'h'
TargetEstrogen receptor(Homo sapiens (Human))
Institut FüR Molekulare Physiologie

Curated by ChEMBL
LigandPNGBDBM50323701(2-(Trifluoroacetyl)-1,2,3,4-tetrahydro-6-isoquinol...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]estradiol from human ERalpha ligand binding domain expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50131550((3S)-3-{[(1S)-1-carbamoyl-2-{4-[difluoro(phosphono...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50341987((S)-4-((S)-1-amino-3-(4-(difluoro(phosphono)methyl...)
Affinity DataKi:  26nMAssay Description:Inhibition of PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 1(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50106497(6-Chloro-7-(2-morpholin-4-yl-ethylamino)-quinoline...)
Affinity DataKi:  29nMAssay Description:Inhibition of human Cdc25AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 3(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50106497(6-Chloro-7-(2-morpholin-4-yl-ethylamino)-quinoline...)
Affinity DataKi:  89nMAssay Description:Inhibition of human Cdc25CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50106497(6-Chloro-7-(2-morpholin-4-yl-ethylamino)-quinoline...)
Affinity DataKi:  95nMAssay Description:Inhibition of human Cdc25BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTYR_PHOSPHATASE_2 domain-containing protein(Mycobacterium tuberculosis)
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50341982(5-(2-cyclohexyl-4-((1-(6-(4-fluoro-2-methylphenyls...)
Affinity DataKi:  150nMAssay Description:Inhibition of Mycobacterium tuberculosis ptpBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTYR_PHOSPHATASE_2 domain-containing protein(Mycobacterium tuberculosis)
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50341985(CHEMBL1765366)
Affinity DataKi:  250nMAssay Description:Inhibition of Mycobacterium tuberculosis ptpBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50607731(CHEMBL5219517)
Affinity DataKi:  313nMAssay Description:Binding affinity to PRMT5/MEP50 (unknown origin) assessed as inhibition constant by FITC- Competitive binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50342004(4-(2-(3-(4-nitrophenyl)-5-oxo-1-phenyl-1H-pyrazol-...)
Affinity DataKi:  700nMAssay Description:Inhibition of SHP-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50607732(CHEMBL5220502)
Affinity DataKi:  862nMAssay Description:Binding affinity to PRMT5/MEP50 (unknown origin) assessed as inhibition constant by FITC- Competitive binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLow molecular weight protein-tyrosine phosphatase A(Mycobacterium tuberculosis)
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50341977(2-(2,5-dimethyl-1H-pyrrol-1-yl)-5-hydroxybenzoic a...)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibition of Mycobacterium tuberculosis ptpAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50607730(CHEMBL5220691)
Affinity DataKi:  1.80E+3nMAssay Description:Binding affinity to PRMT5/MEP50 (unknown origin) assessed as inhibition constant by FITC- Competitive binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTranscriptional enhancer factor TEF-3(Homo sapiens)
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50547124(CHEMBL242708 | NCI-0001009)
Affinity DataKi:  2.60E+3nMAssay Description:Reversible inhibition of CPM binding to nonacylated N-terminal His6-tagged human TEAD4 (217 to 434 residues) expressed in Escherichia coli BL21-Codon...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50341977(2-(2,5-dimethyl-1H-pyrrol-1-yl)-5-hydroxybenzoic a...)
Affinity DataKi:  3.00E+3nMAssay Description:Inhibition of PTP1BMore data for this Ligand-Target Pair
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50607728(CHEMBL5219427)
Affinity DataKi:  4.50E+3nMAssay Description:Binding affinity to PRMT5/MEP50 (unknown origin) assessed as inhibition constant by FITC- Competitive binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50607727(CHEMBL5219049)
Affinity DataKi:  5.10E+3nMAssay Description:Binding affinity to PRMT5/MEP50 (unknown origin) assessed as inhibition constant by FITC- Competitive binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTranscriptional enhancer factor TEF-3(Homo sapiens)
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50547126(CHEMBL4763473)
Affinity DataKi:  1.04E+4nMAssay Description:Inhibition of CPM binding to N-terminal His6-tagged human TEAD4 (217 to 434 residues) expressed in Escherichia coli BL21-CodonPlus (DE3)-RIPL cells p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50607729(CHEMBL5220586)
Affinity DataKi:  6.50E+4nMAssay Description:Binding affinity to PRMT5/MEP50 (unknown origin) assessed as inhibition constant by FITC- Competitive binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50607733(CHEMBL5219642)
Affinity DataKi:  6.60E+4nMAssay Description:Binding affinity to PRMT5/MEP50 (unknown origin) assessed as inhibition constant by FITC- Competitive binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Technical University Dortmund

Curated by ChEMBL
LigandPNGBDBM50543600(CHEMBL4639853)
Affinity DataIC50:  2nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50341988((3S)-4-((2S)-1-amino-3-(4-((((4-chlorobutyl)(methy...)
Affinity DataIC50:  20nMAssay Description:Inhibition of PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 1(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50208827(2,3-bis(2-hydroxyethylthio)naphthalene-1,4-dione |...)
Affinity DataIC50:  22nMAssay Description:Inhibition of human Cdc25AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetActivin receptor type-1(Homo sapiens (Human))
Technical University Dortmund

Curated by ChEMBL
LigandPNGBDBM50261979(5-(6-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-y...)
Affinity DataIC50:  32nMAssay Description:Inhibition of ALK-2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50341990((S)-2-[2-(4-Methoxy-phenyl)-acetylamino]-N-{(S)-1-...)
Affinity DataIC50:  40nMAssay Description:Inhibition of PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 3(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50208827(2,3-bis(2-hydroxyethylthio)naphthalene-1,4-dione |...)
Affinity DataIC50:  56.9nMAssay Description:Inhibition of human Cdc25CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscriptional enhancer factor TEF-3(Homo sapiens)
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50547124(CHEMBL242708 | NCI-0001009)
Affinity DataIC50:  70nMAssay Description:Binding affinity to nonacylated N-terminal His6-tagged human TEAD4 (217 to 434 residues) expressed in Escherichia coli BL21-CodonPlus (DE3)-RIPL cell...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 3(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50303174(2-(5-((3-(4-(2-fluorobenzyloxy)phenyl)-1-phenyl-1H...)
Affinity DataIC50:  74nMAssay Description:Inhibition of VHRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50308840(5-[2-Hydroxy-5-(1H-pyrrol-2-yl)-phenyl]-1,1-dioxo-...)
Affinity DataIC50:  80nMAssay Description:Inhibition of PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscriptional enhancer factor TEF-3(Homo sapiens)
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50547134(CHEMBL4787565)
Affinity DataIC50:  100nMAssay Description:Inhibition of FITC-labeled palmitate tracer binding to N-terminal His6-tagged human TEAD4 (217 to 434 residues) expressed in Escherichia coli BL21-Co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Technical University Dortmund

Curated by ChEMBL
LigandPNGBDBM50004566(9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quinaz...)
Affinity DataIC50:  110nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCasein kinase I isoform delta(Homo sapiens (Human))
Technical University Dortmund

Curated by ChEMBL
LigandPNGBDBM50588635(CHEMBL5186013)
Affinity DataIC50:  120nMAssay Description:Inhibition of CK1delta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50239833((3-bromo-7-cyanonaphthalen-2-yl)difluoromethylphos...)
Affinity DataIC50:  120nMAssay Description:Inhibition of PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50208827(2,3-bis(2-hydroxyethylthio)naphthalene-1,4-dione |...)
Affinity DataIC50:  125nMAssay Description:Inhibition of human Cdc25BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50308839(5-[3'-(6-Fluoro-2,3-dihydro-indol-1-yl)-biphenyl-4...)
Affinity DataIC50:  130nMAssay Description:Inhibition of PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-protein thioesterase 2(Homo sapiens (Human))
Technical University Of Dortmund

LigandPNGBDBM50282567(3,4-Dichlorophenyl boronic acid | 3,4-dichloro ben...)
Affinity DataIC50:  138nMAssay Description:The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50308846(CHEMBL592245 | N-{(S)-1-(1H-Benzoimidazol-2-yl)-2-...)
Affinity DataIC50:  140nMAssay Description:Inhibition of PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Technical University Dortmund

Curated by ChEMBL
LigandPNGBDBM50004566(9-Chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quinaz...)
Affinity DataIC50:  140nMAssay Description:Inhibition of DNA-PK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetM-phase inducer phosphatase 3(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50341995(5-(2-(dimethylamino)ethylamino)-2,6-dimethylbenzo[...)
Affinity DataIC50:  170nMAssay Description:Inhibition of human Cdc25CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscriptional enhancer factor TEF-3(Homo sapiens)
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50547136(CHEMBL4757924)
Affinity DataIC50:  200nMAssay Description:Inhibition of FITC-labeled palmitate tracer binding to N-terminal His6-tagged human TEAD4 (217 to 434 residues) expressed in Escherichia coli BL21-Co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTranscriptional enhancer factor TEF-3(Homo sapiens)
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50547135(CHEMBL4776143)
Affinity DataIC50:  200nMAssay Description:Inhibition of FITC-labeled palmitate tracer binding to N-terminal His6-tagged human TEAD4 (217 to 434 residues) expressed in Escherichia coli BL21-Co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTranscriptional enhancer factor TEF-3(Homo sapiens)
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50547154(CHEMBL4745831)
Affinity DataIC50:  200nMAssay Description:Inhibition of FITC-labeled palmitate tracer binding to N-terminal His6-tagged human TEAD4 (217 to 434 residues) expressed in Escherichia coli BL21-Co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTranscriptional enhancer factor TEF-3(Homo sapiens)
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50547142(CHEMBL4757369)
Affinity DataIC50:  200nMAssay Description:Inhibition of FITC-labeled palmitate tracer binding to N-terminal His6-tagged human TEAD4 (217 to 434 residues) expressed in Escherichia coli BL21-Co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTranscriptional enhancer factor TEF-3(Homo sapiens)
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50547124(CHEMBL242708 | NCI-0001009)
Affinity DataIC50:  200nMAssay Description:Inhibition of FITC-labeled palmitate tracer binding to N-terminal His6-tagged human TEAD4 (217 to 434 residues) expressed in Escherichia coli BL21-Co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTranscriptional enhancer factor TEF-3(Homo sapiens)
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50547146(CHEMBL4745853)
Affinity DataIC50:  200nMAssay Description:Inhibition of FITC-labeled palmitate tracer binding to N-terminal His6-tagged human TEAD4 (217 to 434 residues) expressed in Escherichia coli BL21-Co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform alpha(Homo sapiens (Human))
Technical University Dortmund

Curated by ChEMBL
LigandPNGBDBM50588635(CHEMBL5186013)
Affinity DataIC50:  220nMAssay Description:Inhibition of CK1alpha (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50341993(4-((3-((3-(4-carboxybenzyl)-4-oxo-2-(phenylimino)t...)
Affinity DataIC50:  220nMAssay Description:Inhibition of PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTYR_PHOSPHATASE_2 domain-containing protein(Mycobacterium tuberculosis)
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM26104(5-{2-cyclohexyl-4-[4-fluoro-3-(trifluoromethyl)phe...)
Affinity DataIC50:  220nMAssay Description:Inhibition of Mycobacterium tuberculosis ptpBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Max Planck Institute Of Molecular Physiology

Curated by ChEMBL
LigandPNGBDBM50341994(2-(((5-tert-butylthiazol-2-yl)methyl)((4-(4-((4-(h...)
Affinity DataIC50:  220nMAssay Description:Inhibition of PTP1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-protein thioesterase 2(Homo sapiens (Human))
Technical University Of Dortmund

LigandPNGBDBM92722(Phenylboronic acid, 15)
Affinity DataIC50:  238nMAssay Description:The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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