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Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM50189659
Substrate
n/a
Meas. Tech.
ChEMBL_368413 (CHEMBL870503)
IC50
16±n/a nM
Citation
 Combs, AP; Zhu, W; Crawley, ML; Glass, B; Polam, P; Sparks, RB; Modi, D; Takvorian, A; McLaughlin, E; Yue, EW; Wasserman, Z; Bower, M; Wei, M; Rupar, M; Ala, PJ; Reid, BM; Ellis, D; Gonneville, L; Emm, T; Taylor, N; Yeleswaram, S; Li, Y; Wynn, R; Burn, TC; Hollis, G; Liu, PC; Metcalf, B Potent benzimidazole sulfonamide protein tyrosine phosphatase 1B inhibitors containing the heterocyclic (S)-isothiazolidinone phosphotyrosine mimetic. J Med Chem 49:3774-89 (2006) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:
Protein phosphatase
Mol. Mass.:
49963.76
Organism:
Homo sapiens (Human)
Description:
Human recombinant GST-fusion PTP1B (1-435).
Residue:
435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
  
Inhibitor
Name:
BDBM50189659
Synonyms:
CHEMBL378614 | N-((1S)-1-(1H-benzimidazol-2-yl)-2-{4-[(5S)-1,1-dioxodo-3-oxoisothiazolidin-5-yl]-3-methylphenyl}ethyl0benzenesulfonamide
Type:
Small organic molecule
Emp. Form.:
C26H21BrF3N4O5S2
Mol. Mass.:
670.498
SMILES:
Cc1cc(C[C@H](NS(=O)(=O)c2ccc(Br)c(c2)C(F)(F)F)c2nc3ccccc3[nH]2)ccc1[C@@H]1CC(=O)[N-]S1(=O)=O
Structure:
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