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Target
Sodium/hydrogen exchanger 2
Ligand
BDBM50191831
Substrate
n/a
Meas. Tech.
ChEMBL_397781 (CHEMBL856312)
IC50
9000±n/a nM
Citation
 Atwal, KS; O'Neil, SV; Ahmad, S; Doweyko, L; Kirby, M; Dorso, CR; Chandrasena, G; Chen, BC; Zhao, R; Zahler, R Synthesis and biological activity of 5-aryl-4-(4-(5-methyl-1H-imidazol-4-yl)piperidin-1-yl)pyrimidine analogs as potent, highly selective, and orally bioavailable NHE-1 inhibitors. Bioorg Med Chem Lett 16:4796-9 (2006) [PubMed]  Article 
Target
Name:
Sodium/hydrogen exchanger 2
Synonyms:
NHE-2 | NHE2 | Na(+)/H(+) exchanger 2 | SL9A2_HUMAN | SLC9A2 | Solute carrier family 9 member 2
Type:
PROTEIN
Mol. Mass.:
91542.38
Organism:
Homo sapiens (Human)
Description:
ChEMBL_397781
Residue:
812
Sequence:
MEPLGNWRSLRAPLPPMLLLLLLQVAGPVGALAETLLNAPRAMGTSSSPPSPASVVAPGTTLFEESRLPVFTLDYPHVQIPFEITLWILLASLAKIGFHLYHKLPTIVPESCLLIMVGLLLGGIIFGVDEKSPPAMKTDVFFLYLLPPIVLDAGYFMPTRPFFENIGTIFWYAVVGTLWNSIGIGVSLFGICQIEAFGLSDITLLQNLLFGSLISAVDPVAVLAVFENIHVNEQLYILVFGESLLNDAVTVVLYNLFKSFCQMKTIETIDVFAGIANFFVVGIGGVLIGIFLGFIAAFTTRFTHNIRVIEPLFVFLYSYLSYITAEMFHLSGIMAITACAMTMNKYVEENVSQKSYTTIKYFMKMLSSVSETLIFIFMGVSTVGKNHEWNWAFVCFTLAFCLMWRALGVFVLTQVINRFRTIPLTFKDQFIIAYGGLRGAICFALVFLLPAAVFPRKKLFITAAIVVIFFTVFILGITIRPLVEFLDVKRSNKKQQAVSEEIYCRLFDHVKTGIEDVCGHWGHNFWRDKFKKFDDKYLRKLLIRENQPKSSIVSLYKKLEIKHAIEMAETGMISTVPTFASLNDCREEKIRKVTSSETDEIRELLSRNLYQIRQRTLSYNRHSLTADTSERQAKEILIRRRHSLRESIRKDSSLNREHRASTSTSRYLSLPKNTKLPEKLQKRRTISIADGNSSDSDADAGTTVLNLQPRARRFLPEQFSKKSPQSYKMEWKNEVDVDSGRDMPSTPPTPHSREKGTQTSGLLQQPLLSKDQSGSEREDSLTEGIPPKPPPRLVWRASEPGSRKARFGSEKP
  
Inhibitor
Name:
BDBM50191831
Synonyms:
5-(4-fluoro-3-methylphenyl)-2-methoxy-4-(4-(4-methyl-1H-imidazol-5-yl)piperidin-1-yl)pyrimidine | CHEMBL217698
Type:
Small organic molecule
Emp. Form.:
C21H24FN5O
Mol. Mass.:
381.4466
SMILES:
COc1ncc(-c2ccc(F)c(C)c2)c(n1)N1CCC(CC1)c1[nH]cnc1C
Structure:
Search PDB for entries with ligand similarity: