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Target
Serine/threonine-protein kinase B-raf
Ligand
BDBM50215778
Substrate
n/a
Meas. Tech.
ChEMBL_456550 (CHEMBL922916)
IC50
39±n/a nM
Citation
Wickens, P; Kluender, H; Dixon, J; Brennan, C; Achebe, F; Bacchiocchi, A; Bankston, D; Bierer, D; Brands, M; Braun, D; Brown, MS; Chuang, CY; Dumas, J; Enyedy, I; Hofilena, G; Hong, Z; Housley, T; Jones, B; Khire, U; Kreiman, C; Kumarasinghe, E; Lowinger, T; Ott-Morgan, R; Perkins, L; Phillips, B; Schoenleber, R; Scott, WJ; Sheeler, R; Redman, A; Sun, X; Taylor, I; Wang, L; Wilhelm, S; Zhang, X; Zhang, M; Sullivan, E; Carter, C; Miglarese, M; Levy, J SAR of a novel 'Anthranilamide Like' series of VEGFR-2, multi protein kinase inhibitors for the treatment of cancer. Bioorg Med Chem Lett 17:4378-81 (2007) [PubMed] Article
More Info.:
Target
Name:
Serine/threonine-protein kinase B-raf
Synonyms:
B-RAF | B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | p94 | v-Raf murine sarcoma viral oncogene homolog B1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
84446.00
Organism:
Homo sapiens (Human)
Description:
P15056
Residue:
766
Sequence:
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
Inhibitor
Name:
BDBM50215778
Synonyms:
1-(4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carbamoyl)phenylamino)methyl)pyridin-2-yl)-3-phenylurea | CHEMBL397345
Type:
Small organic molecule
Emp. Form.:
C27H21F2N5O4
Mol. Mass.:
517.4835
SMILES:
FC1(F)Oc2ccc(NC(=O)c3ccccc3NCc3ccnc(NC(=O)Nc4ccccc4)c3)cc2O1