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Target
Beta-3 adrenergic receptor
Ligand
BDBM50224021
Substrate
n/a
Meas. Tech.
ChEMBL_458278 (CHEMBL924524)
EC50
6.5±n/a nM
Citation
 Stevens, FC; Bloomquist, WE; Borel, AG; Cohen, ML; Droste, CA; Heiman, ML; Kriauciunas, A; Sall, DJ; Tinsley, FC; Jesudason, CD Potent oxindole based human beta3 adrenergic receptor agonists. Bioorg Med Chem Lett 17:6270-3 (2007) [PubMed]  Article 
Target
Name:
Beta-3 adrenergic receptor
Synonyms:
ADRB3_RAT | Adrb3 | Adrb3r | Adrenergic receptor beta | Beta-3 adrenergic receptor
Type:
PROTEIN
Mol. Mass.:
43161.83
Organism:
Rattus norvegicus
Description:
ChEMBL_1509452
Residue:
400
Sequence:
MAPWPHKNGSLAFWSDAPTLDPSAANTSGLPGVPWAAALAGALLALATVGGNLLVITAIARTPRLQTITNVFVTSLATADLVVGLLVMPPGATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGTLVTKRRARAAVVLVWIVSATVSFAPIMSQWWRVGADAEAQECHSNPRCCSFASNMPYALLSSSVSFYLPLLVMLFVYARVFVVAKRQRRLLRRELGRFPPEESPRSPSRSPSPATVGTPTASDGVPSCGRRPARLLPLGEHRALRTLGLIMGIFSLCWLPFFLANVLRALVGPSLVPSGVFIALNWLGYANSAFNPLIYCRSPDFRDAFRRLLCSYGGRGPEEPRVVTFPASPVASRQNSPLNRFDGYEGERPFPT
  
Inhibitor
Name:
BDBM50224021
Synonyms:
(S)-6-(4-(2-(3-(3,3-dimethyl-2-oxoindolin-4-yloxy)-2-hydroxypropylamino)-2-methylpropyl)phenoxy)nicotinamide | CHEMBL251372
Type:
Small organic molecule
Emp. Form.:
C29H34N4O5
Mol. Mass.:
518.6041
SMILES:
CC(C)(Cc1ccc(Oc2ccc(cn2)C(N)=O)cc1)NC[C@H](O)COc1cccc2NC(=O)C(C)(C)c12
Structure:
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