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Target
Proto-oncogene Wnt-3
Ligand
BDBM50265468
Substrate
n/a
Meas. Tech.
ChEMBL_560815 (CHEMBL1012645)
EC50
620±n/a nM
Citation
 Moore, WJ; Kern, JC; Bhat, R; Commons, TJ; Fukayama, S; Goljer, I; Krishnamurthy, G; Magolda, RL; Nogle, L; Pitts, K; Stauffer, B; Trybulski, EJ; Welmaker, GS; Wilson, M; Bodine, PV Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides. J Med Chem 52:105-16 (2009) [PubMed]  Article 
Target
Name:
Proto-oncogene Wnt-3
Synonyms:
INT4 | Proto-oncogene protein Wnt-3 | WNT3 | WNT3_HUMAN
Type:
PROTEIN
Mol. Mass.:
39653.31
Organism:
Homo sapiens (Human)
Description:
ChEMBL_576549
Residue:
355
Sequence:
MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK
  
Inhibitor
Name:
BDBM50265468
Synonyms:
CHEMBL497177 | N-[1-(N-Methylglycyl)piperidin-4-yl]-5-(phenylsulfonyl)-2-(trifluoromethyl)-benzenesulfonamide
Type:
Small organic molecule
Emp. Form.:
C21H24F3N3O5S2
Mol. Mass.:
519.558
SMILES:
CNCC(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1
Structure:
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