Reaction Details Report a problem with these data
Target
Monoglyceride lipase
Ligand
BDBM50295686
Substrate
n/a
Meas. Tech.
ChEMBL_577779 (CHEMBL1053086)
IC50
3300±n/a nM
Citation
 Minkkilä, A; Myllymäki, MJ; Saario, SM; Castillo-Melendez, JA; Koskinen, AM; Fowler, CJ; Leppänen, J; Nevalainen, T The synthesis and biological evaluation of para-substituted phenolic N-alkyl carbamates as endocannabinoid hydrolyzing enzyme inhibitors. Eur J Med Chem 44:2994-3008 (2009) [PubMed]  Article 
Target
Name:
Monoglyceride lipase
Synonyms:
MAGL | MGLL_RAT | Mgl2 | Mgll | Monoacylglycerol lipase | Monoglyceride lipase | Monoglyceride lipase (MGL)
Type:
Enzyme
Mol. Mass.:
33505.38
Organism:
Rattus norvegicus (Rat)
Description:
Q8R431
Residue:
303
Sequence:
MPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKALIFVSHGAGEHCGRYDELAQMLKRLDMLVFAHDHVGHGQSEGERMVVSDFQVFVRDLLQHVNTVQKDYPEVPVFLLGHSMGGAISILAAAERPTHFSGMILISPLILANPESASTLKVLAAKLLNFVLPNISLGRIDSSVLSRNKSEVDLYNSDPLICHAGVKVCFGIQLLNAVSRVERAMPRLTLPFLLLQGSADRLCDSKGAYLLMESSPSQDKTLKMYEGAYHVLHKELPEVTNSVLHEINTWVSHRIAVAGARCLP
  
Inhibitor
Name:
BDBM50295686
Synonyms:
4-(Dodecylcarbamoyloxy)benzoic acid methyl ester | CHEMBL552117
Type:
Small organic molecule
Emp. Form.:
C21H33NO4
Mol. Mass.:
363.491
SMILES:
CCCCCCCCCCCCNC(=O)Oc1ccc(cc1)C(=O)OC
Structure:
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