Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 2C
Ligand
BDBM50298354
Substrate
n/a
Meas. Tech.
ChEMBL_588489 (CHEMBL1040387)
IC50
20.1±n/a nM
Citation
 Ahmed, A; Choo, H; Cho, YS; Park, WK; Pae, AN Identification of novel serotonin 2C receptor ligands by sequential virtual screening. Bioorg Med Chem 17:4559-68 (2009) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2C
Synonyms:
5-HT-1C | 5-HT-2C | 5-HT1C | 5-HT2C | 5-HT2C-INI | 5-HT2c VGI | 5-HTR2C | 5-hydroxytryptamine receptor 1C | 5-hydroxytryptamine receptor 2C (5-HT-2C) | 5-hydroxytryptamine receptor 2C (5HT-2C) | 5HT-1C | 5HT2C_HUMAN | HTR1C | HTR2C | Serotonin (5-HT3) receptor | Serotonin 2c (5-HT2c) receptor | Serotonin Receptor 2C
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
51836.79
Organism:
Homo sapiens (Human)
Description:
P28335
Residue:
458
Sequence:
MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
  
Inhibitor
Name:
BDBM50298354
Synonyms:
CHEMBL578653 | N-(4-fluorophenyl)-1-methyl-6-(4-methylpiperazin-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Type:
Small organic molecule
Emp. Form.:
C17H20FN7
Mol. Mass.:
341.386
SMILES:
CN1CCN(CC1)c1nc(Nc2ccc(F)cc2)c2cnn(C)c2n1
Structure:
Search PDB for entries with ligand similarity: