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Target
Beta-secretase 1
Ligand
BDBM50299238
Substrate
n/a
Meas. Tech.
ChEMBL_589296 (CHEMBL1045676)
Ki
295±n/a nM
Citation
 Al-Tel, TH; Al-Qawasmeh, RA; Schmidt, MF; Al-Aboudi, A; Rao, SN; Sabri, SS; Voelter, W Rational design and synthesis of potent dibenzazepine motifs as beta-secretase inhibitors. J Med Chem 52:6484-8 (2009) [PubMed]  Article 
Target
Name:
Beta-secretase 1
Synonyms:
ASP2 | Asp 2 | Aspartyl protease 2 | BACE | BACE1 | BACE1_HUMAN | Beta-secretase (BACE) | Beta-secretase 1 | Beta-secretase 1 (BACE 1) | Beta-secretase 1 (BACE-1) | Beta-secretase 1 (BACE1) | Beta-site APP cleaving enzyme 1 | Beta-site amyloid precursor protein cleaving enzyme 1 | KIAA1149 | Memapsin-2 | Membrane-associated aspartic protease 2 | beta-Secretase (BACE-1) | beta-Secretase (BACE1)
Type:
Protein
Mol. Mass.:
55755.10
Organism:
Homo sapiens (Human)
Description:
P56817
Residue:
501
Sequence:
MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK
  
Inhibitor
Name:
BDBM50299238
Synonyms:
CHEMBL578437 | Methyl 11-Oxo-N-(pyridin-4-yl)-10,11-dihydro-5H-dibenzo-[b,e][1,4]diazepine-3-carboxamide
Type:
Small organic molecule
Emp. Form.:
C19H14N4O2
Mol. Mass.:
330.3401
SMILES:
O=C(Nc1ccncc1)c1ccc2c(Nc3ccccc3NC2=O)c1
Structure:
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