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Target
Elongation of very long chain fatty acids protein 6
Ligand
BDBM50299948
Substrate
n/a
Meas. Tech.
ChEMBL_592844 (CHEMBL1045787)
IC50
26.0±n/a nM
Citation
Mizutani, T; Ishikawa, S; Nagase, T; Takahashi, H; Fujimura, T; Sasaki, T; Nagumo, A; Shimamura, K; Miyamoto, Y; Kitazawa, H; Kanesaka, M; Yoshimoto, R; Aragane, K; Tokita, S; Sato, N Discovery of novel benzoxazinones as potent and orally active long chain fatty acid elongase 6 inhibitors. J Med Chem 52:7289-300 (2009) [PubMed] Article
More Info.:
Target
Name:
Elongation of very long chain fatty acids protein 6
Synonyms:
ELOV6_HUMAN | ELOVL6 | FACE | LCE
Type:
PROTEIN
Mol. Mass.:
31392.28
Organism:
Homo sapiens (Human)
Description:
ChEMBL_572238
Residue:
265
Sequence:
MNMSVLTLQEYEFEKQFNENEAIQWMQENWKKSFLFSALYAAFIFGGRHLMNKRAKFELRKPLVLWSLTLAVFSIFGALRTGAYMVYILMTKGLKQSVCDQGFYNGPVSKFWAYAFVLSKAPELGDTIFIILRKQKLIFLHWYHHITVLLYSWYSYKDMVAGGGWFMTMNYGVHAVMYSYYALRAAGFRVSRKFAMFITLSQITQMLMGCVVNYLVFCWMQHDQCHSHFQNIFWSSLMYLSYLVLFCHFFFEAYIGKMRKTTKAE
Inhibitor
Name:
BDBM50299948
Synonyms:
CHEMBL572158 | N-{[(+)-6-Chloro-2-oxo-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-4-yl]methyl}-4-fluorobenzamide | N-{[(-)-6-Chloro-2-oxo-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-4-yl]methyl}-4-fluorobenzamide | N-{[6-Chloro-2-oxo-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-4-yl]methyl}-4-fluorobenzamide
Type:
Small organic molecule
Emp. Form.:
C17H11ClF4N2O3
Mol. Mass.:
402.727
SMILES:
Fc1ccc(cc1)C(=O)NCC1(OC(=O)Nc2ccc(Cl)cc12)C(F)(F)F