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Target
Tyrosine-protein kinase Lck
Ligand
BDBM50301605
Substrate
n/a
Meas. Tech.
ChEMBL_600521 (CHEMBL1049046)
IC50
0.2±n/a nM
Citation
 Hunt, JA; Beresis, RT; Goulet, JL; Holmes, MA; Hong, XJ; Kovacs, E; Mills, SG; Ruzek, RD; Wong, F; Hermes, JD; Park, YW; Salowe, SP; Sonatore, LM; Wu, L; Woods, A; Zaller, DM; Sinclair, PJ Disubstituted pyrimidines as Lck inhibitors. Bioorg Med Chem Lett 19:5440-3 (2009) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase Lck
Synonyms:
2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase
Type:
n/a
Mol. Mass.:
57987.83
Organism:
Homo sapiens (Human)
Description:
P06239
Residue:
509
Sequence:
MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP
  
Inhibitor
Name:
BDBM50301605
Synonyms:
(S)-3-((S)-1-(4-(1H-benzo[d]imidazol-1-yl)pyrimidin-2-ylamino)ethyl)-4-isobutyl-N-(naphthalen-1-yl)piperazine-1-carboxamide | CHEMBL568762
Type:
Small organic molecule
Emp. Form.:
C32H36N8O
Mol. Mass.:
548.6812
SMILES:
CC(C)CN1CCN(C[C@H]1[C@H](C)Nc1nccc(n1)-n1cnc2ccccc12)C(=O)Nc1cccc2ccccc12 |r|
Structure:
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